Publications associées à Maladie métabolique

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Johan Auwerx, Laurent Mouchiroud, Adrienne Joëlle Laurence Mottis

Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge ...

Cold Spring Harbor Laboratory Press2013

Evolution of the Hepatic Lipid Profile of the Adult Mouse - in Vivo and in Vitro 1H MRS Assessments at 14.1T

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

The hepatic lipid content and composition were assessed in healthy mice throughout adulthood. It was found that aging and obesity contributed to increase the amount of lipids in the liver while decreasing the poly-unsaturation degree. The combination of in ...

2013

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Methods of treating mitochondrial dysfunction

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

2013

Utilization of NMR spectroscopy to study biological fluids and metabolic processes: Two introductory activities

Luciano Andres Abriata

This work describes two activities designed to introduce students into the use of NMR spectroscopy for the analysis of biological fluids. In the first activity, 1H spectra of common beverages are acquired and analyzed to identify their most abundant consti ...

Wiley-Blackwell2012

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Karl Gademann, Richardus Houtkooper, Eija Riitta Pirinen, Hiroyasu Yamamoto, Maaike Hélène Oosterveer, Pablo Jose Fernandez Marcos

As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+ ...

Elsevier2012

Ncor1 is a physiological modulator of muscle mass and oxidative function

Johan Auwerx, Laurent Mouchiroud, Hiroyasu Yamamoto

The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...

2012

Exploring the therapeutic space around NAD+

Johan Auwerx, Richardus Houtkooper

NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegenerati ...

Rockefeller University Press2012

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Maladie métabolique

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

Evolution of the Hepatic Lipid Profile of the Adult Mouse - in Vivo and in Vitro 1H MRS Assessments at 14.1T

Mitonuclear protein imbalance as a conserved longevity mechanism

Methods of treating mitochondrial dysfunction

Utilization of NMR spectroscopy to study biological fluids and metabolic processes: Two introductory activities

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Ncor1 is a physiological modulator of muscle mass and oxidative function

Exploring the therapeutic space around NAD+

Graph Chatbot

Chattez avec Graph Search

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Evolution of the Hepatic Lipid Profile of the Adult Mouse - in Vivo and in Vitro 1H MRS Assessments at 14.1T

Utilization of NMR spectroscopy to study biological fluids and metabolic processes: Two introductory activities

Mitonuclear protein imbalance as a conserved longevity mechanism

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

Methods of treating mitochondrial dysfunction

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Ncor1 is a physiological modulator of muscle mass and oxidative function

Exploring the therapeutic space around NAD+