Concept

Rétrovirus endogène

Publications associées (49)

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Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

Didier Trono, Priscilla Turelli, Bastien Mangeat

During the early phase of the retroviral life cycle, only a fraction of internalized virions end up integrating their genome into the chromosome, even though the resulting proviruses are almost systematically expressed. Here, we reveal that incoming retrov ...

2001

Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

Didier Trono

We exploited the ability of lentiviral vectors to govern the stable transduction of cells irrespective of their cycling status to induce the reversible immortalization of human primary cells. First, bicistronic HIV-derived lentiviral vectors expressing GFP ...

2000

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

Didier Trono, Romain Zufferey

In vivo transduction of nondividing cells by human immunodeficiency virus type 1 (HIV-1)-based vectors results in transgene expression that is stable over several months. However, the use of HIV-1 vectors raises concerns about their safety. Here we describ ...

American Society for Microbiology1998

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

Didier Trono

The karyophilic properties of the HIV-1 nucleoprotein complex facilitate infection of nondividing cells such as macrophages and quiescent T lymphocytes, and allow the in vivo delivery of transgenes by HIV-derived retroviral vectors into terminally differen ...

1997

A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polym ...

1995

Papillomaviruses are believed to play an important role in the development of genital carcinoma. Herpes simplex virus (HSV) has been proposed as a cofactor. Here we show that HSV-1 interferes with the expression of human papillomavirus (HPV-18) genes in He ...

1993

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages

Lukas Kühn

Biosynthesis of nitric oxide (NO) from L-arginine modulates activity of iron-dependent enzymes, including mitochondrial acontiase, an [Fe-S] protein. We examined the effect of NO on the activity of iron regulatory factor (IRF), a cytoplasmic protein which ...

1993

Defective endogenous retrovirus-like sequences and particles of Chinese hamster ovary cells

Florian Maria Wurm

The presence of budding C-type and intracytoplasmic A-type particles in Chinese hamster ovary (CHO) cells is well documented. However, extensive screening has failed to detect any evidence of infectivity. To investigate the origin and expression of these p ...

1991

We have looked for the binding of several HOX4 complex homeoproteins in the genomic region containing the HOX4C promoter, between the human HOX4C and HOX4D genes. The HOX4C, HOX4D and Hox-4.3 homeoproteins bind to a phylogenetically highly conserved DNA fr ...

1991