Concept

Lissencéphalie

Publications associées (32)

Neuronal migration prevents spatial competition in retinal morphogenesis

The concomitant occurrence of tissue growth and organization is a hallmark of organismal development(1-3). This often means that proliferating and differentiating cells are found at the same time in a continuously changing tissue environment. How cells ada ...

NATURE PORTFOLIO2023

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Sean Lewis Hill, Mohameth François Sy

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

HUMANA PRESS INC2022

First-person body view modulates the neural substrates of episodic memory and autonoetic consciousness: A functional connectivity study

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Bruno Herbelin, Thomas William Arthur Bolton, Florian Lance, Nathan Quentin Faivre, Robin Mange, Baptiste Gauthier, Lucie Bréchet

Episodic memory (EM) is classically conceived as a memory for events, localized in space and time, and characterized by autonoetic consciousness (ANC) allowing to mentally travel back in time and subjectively relive an event. Building on recent evidence th ...

2020

Towards a supervised classification of neocortical interneuron morphologies

Sean Lewis Hill, Ruth Benavides Piccione, Bojan Mihaljevic

BackgroundThe challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.ResultsWe trained models using 217 high-quality morphologies of rat so ...

BMC2018

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Silvestro Micera, Grégoire Courtine, Marco Bonizzato, Polina Shkorbatova, Natalia Pavlova, Galyna Pidpruzhnykova

The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...

Nature Publishing Group2018

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks

Silvestro Micera

Epilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined ...

Springer Heidelberg2016

Mechanisms of centrosome separation in C. elegans

Alessandro De Simone

Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...

EPFL2016

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

Henry Markram, Srikanth Ramaswamy

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: Pathophysiological relevance for Alzheimer's disease?

Johan Auwerx

Apolipoprotein E (ApoE) is found in three different forms in humans (ApoE2, ApoE3 and ApoE4), and ApoE polymorphism is recognized as a major risk factor for Alzheimer's disease (AD). ApoE is involved in lipid and cholesterol transport, cell repair, and amy ...

Elsevier2014

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

Henry Markram, Yun Wang, Shruti Muralidhar

Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...

Frontiers Research Foundation2014

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