Concept

Allosteric modulator

Publications associées (54)

Online Modulation of the Level of Assistance in Shared Control Systems

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Robert Leeb, Tom Edward Carlson

In this paper we propose a method to modulate the level of assistance provided by a shared controller, not only given the environmental context, but also according to the context of the user’s current behaviour. We show that the enhanced situational contex ...

2012

Efficient orange light-emitting electrochemical cells

Michael Graetzel, Mohammad Khaja Nazeeruddin, Rosario Scopelliti

We report the first bis-cyclometalated cationic iridium(III) complex with N-aryl-substituted 1H-imidazo [4,5-f][1,10]phenanthroline. The complex emits yellow-orange phosphorescence with a maximum at 583 nm, a quantum yield of 43%, and an excited-state life ...

Royal Society of Chemistry2012

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

General anaesthetics have enjoyed long and widespread use but their molecular mechanism of action remains poorly understood. There is good evidence that their principal targets are pentameric ligand-gated ion channels (pLGICs) such as inhibitory GABA(A) (γ ...

Nature Publishing Group2011

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

Oliver Hantschel

Chronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr-Abl and treated with the tyrosine kinase inhibitor (TKI) imatinib. However, emerging TKI resistance prevents complete cure. Therefore, alternative strategies targ ...

2011

Global gene expression analysis of rodent motor neurons following spinal cord injury associates molecular mechanisms with development of postinjury spasticity

Jesper Ryge

Spinal cord injury leads to severe problems involving impaired motor, sensory, and autonomic functions. After spinal injury there is an initial phase of hyporeflexia followed by hyperreflexia, often referred to as spasticity. Previous studies have suggeste ...

American Physiological Society2009

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

Ursula Röthlisberger, Hilal Lashuel, Michele Cascella, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk

Macrophage migration inhibitory factor (MIF) is a multifunctional protein and a major mediator of innate immunity. Although X-ray crystallography revealed that MIF exists as a homotrimer, its oligomerization state in vivo and the factors governing its olig ...

American Chemical Society2008

Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms

Paul Joseph Dyson, Wee Han Ang, Andrew Douglas Phillips, Claudine Scolaro, Gianni Sava

Organometallic ruthenium(II) complexes of the general formula [Ru(η6-p-cymene)Cl2(L)] and [Ru(η6-p-cymene)Cl(L)2][BPh4] with modified phenoxazine- and anthracene-based multidrug resistanc ...

2007

Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators

Pierre Magistretti, Luc Pellerin

Glutamate was previously shown to enhance aerobic glycolysis i.e. increase glucose utilization and lactate production with no change in oxygen levels, in mouse cortical astrocytes by a mechanism involving glutamate uptake. It is reported here that a simila ...

2005

Cofactor-based screening method for nuclear receptor modulators and related modulators

Johan Auwerx

The invention relates to methods that enable identification of modulators of nuclear receptor (NR) activity and to methods for treating and/or preventing diseases or pathologic conditions associated with cell types that express said nuclear receptors. More ...

2003

An optical modulator

Luc Thévenaz

An optical modulator is arranged to compensate for the thermo-optical modulating effects induced by charge-injection based phase modulators. It comprises first modulator means (3), that receive optical radiation (11, 21), direct it along an optical path, a ...

World Intellectual Property Organization2003

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