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Over the past few years, several genes involved in the development of the tetrapod limbs have been isolated and characterized. Thus, it becomes possible to study some of the developmental mechanisms responsible for the morphogenesis of these complex struct ...
This thesis is the first to be carried out within the framework of the project "Cyberthosis for Paraplegics" in progress at the "Laboratoire de Systèmes Robotiques" (LSRO) of the "Ecole Polytechnique Fédérale de Lausanne" (EPFL). This project, initiated in ...
Vertebrate HoxA and HoxD cluster genes are required for proper limb development. However, early lethality, compensation and redundancy have made a full assessment of their function difficult. Here we describe mice that are lacking all Hoxa and Hoxd functio ...
During knee flexion, the human patella moves along a complex path resulting from the combined actions of articular contact and soft-tissue stabilization. The current study is an attempt to characterize the role of these soft structures on patellar kinemati ...
The tyrosine kinase c-Abl is inactivated by interactions made by its SH3 and SH2 domains with the distal surface of the kinase domain. We present a crystal structure of a fragment of c-Abl which reveals that a critical N-terminal cap segment, not visualize ...
Performing multi-joint arm movements in controllable dynamic environments during functional magnetic resonance imaging (fMRI) could provide important insights into the brain mechanisms involved in human motor control and related dysfunctions. In order to o ...
Object. The authors describe a new method of localizing electrodes on magnetic resonance (MR) images and focus on the positions of both the most efficient contact and the electrode related to the MR imaging target. Methods. Thirty-one patients who had unde ...
Computer Graphics came into the medical world especially after the arrival of 3D medical imaging. Computer Graphics techniques are already integrated in the diagnosis procedure by means of the visual tridimensional analysis of computer tomography, magnetic ...
Cytochrome c peroxidase (I) from Saccharomyces cerevisiae was subjected to directed mol. evolution to generate mutants with increased activity against ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)]. Using a combination of DNA shuffling and s ...
Genes belonging to both HoxA and HoxD clusters are required for proper vertebrate limb development. Mice lacking all, or parts of, Hoxa and Hoxd functions in forelimbs, as well as mice with a gain of function of these genes in the early limb bud, have help ...
