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The development of efficient chiral monodentate phosphine ligands lags behind that of the bidentate congeners. This holds especially true for highly electron rich chiral phosphine analogues able to replace the ubiquitous tricyclohexylphosphine and tri-tert ...
Oxidative addition of BrC CC(=O)O-menthyl (1a) to [Pd(PPh3)(4)] affords the alkynyl complex trans-[Br(PPh3)(2)Pd-C CC(=O)O-menthyl] (2a). Subsequent reaction of 2a with trifluoroacetate gives trans-[(F3CCOO)(PPh3)(2)Pd-C CC(=O)O-menthyl] (3a). Reaction of ...
Two new bis(diphenylphosphino) amines, N,N-bis(diphenylphosphino) benzidine 1 and N, N-bis(diphenylphosphino)- 3,3-dimethoxybenzidine 2 were prepared by aminolysis. Their corresponding oxides, sulfides and selenides were readily prepared by reaction with h ...
A combined DFT/vibrational spectroscopy approach is used to determine the interactions of the 1,3-dimethylimidazolium ([Mmim]+) and 1-ethyl-3-methylimidazolium ([Emim]+) cations and [BF4]- anions with each other in the liquid state and with Pd nanoparticle ...
A series of hydrophilic N,N-dimethylpyrrolidinium-and N,N-dimethylpiperidinium-based ionic liquids (ILs) have been prepared and applied as reaction media in the Wacker oxidation of styrene by hydrogen peroxide using PdCl2 as the catalyst. The efficiency of ...
Four new bis(phosphino)amine ligands (Ph2P)2N-C6H3-R, where R = 3,5-OMe (1), 2,5-OMe (2), 2,4-OMe (3) or 3,4-OMe (4), were prepd. via aminolysis of the corresponding dimethoxyanilines with 2 equiv. of diphenylphosphine chloride in the presence of tri-Et am ...
The goal of this thesis is to develop new carbon-carbon bond forming reactions using inexpensive and simple coupling partners like aryl halides (pseudohalides), sulfonyl derivatives, Grignard reagents, alkenes and alkynes with metal catalysis, preferably u ...
Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl h ...
Product development (PD) processes are complex and unstructured compared to business or manufacturing processes, as they have iterative, evolutionary, uncertain, and cooperative features. In order to effectively manage and control a complex PD process, app ...