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Bioconductor

Publications associées (13)

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each

Lukas Kühn, Giovanna Ambrosini, Barbara Grisoni-Neupert, Philipp Bucher, Ramona Pauchard-Batschulat, Otto Hagenbüchle

Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...

PUBLIC LIBRARY SCIENCE2018

Development of topological tools for the analysis of biological data

There is a growing need for unbiased clustering algorithms, ideally automated to analyze complex data sets. Topological data analysis (TDA) has been used to approach this problem. This recent field of mathematics discerns characteristic features of a space ...

EPFL2018

Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly

Johan Auwerx, Pénélope Andreux

Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia. While these two conditions are well characterized, further investigation of the early biological ...

2018

On generalizability of MOOC models

Pierre Dillenbourg, Kshitij Sharma, Mina Shirvani Boroujeni

The big data imposes the key problem of generalizability of the results. In the present contribution, we discuss statistical tools which can help to select variables adequate for target level of abstraction. We show that a model considered as over-fitted i ...

2016

Personal receptor repertoires: olfaction as a model

Sebastian Martin Waszak

Background: Information on nucleotide diversity along completely sequenced human genomes has increased tremendously over the last few years. This makes it possible to reassess the diversity status of distinct receptor proteins in different human individual ...

BioMed Central2012

Genomics and transcriptomics of the Mycobacterium tuberculosis complex

Swapna Uplekar

The goal of eliminating tuberculosis (TB) by 2050 depends on the development of improved TB diagnostics, drugs and vaccines. Advances in these areas require a deep understanding of the disease and its causative agent, Mycobacterium tuberculosis (M. tb). My ...

EPFL2012

Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster

Drosophila melanogaster is one of the most important genetic models and techniques such as reverse transcription quantitative real-time PCR (RT-qPCR) are being employed extensively for deciphering the genetics basis of physiological functions. In RT-qPCR, ...

Elsevier2011

Use of consensus sequences for the design of high density resequencing microarrays: the influenza virus paradigm

Stewart Cole, Iain Old

BACKGROUND: A resequencing microarray called PathogenID v2.0 has been developed and used to explore various strategies of sequence selection for its design. The part dedicated to influenza viruses was based on consensus sequences specific for one gene gene ...

BioMed Central2010

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

Mauro Delorenzi

BACKGROUND: The variety of DNA microarray formats and datasets presently available offers an unprecedented opportunity to perform insightful comparisons of heterogeneous data. Cross-species studies, in particular, have the power of identifying conserved, f ...

BioMed Central2008

Gene expression profiling of two distinct neuronal populations in the rodent spinal cord

Jesper Ryge

BACKGROUND: In the field of neuroscience microarray gene expression profiles on anatomically defined brain structures are being used increasingly to study both normal brain functions as well as pathological states. Fluorescent tracing techniques in brain t ...

Public Library of Science2008

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