The Little Applegate River is a tributary of the Applegate River located in the U.S. state of Oregon. It is part of the Rogue River watershed, draining approximately of Jackson County. Rising in the Siskiyou Mountains, the river flows generally northwest to meet the Applegate about northwest of Buncom and south of Ruch.
The Little Applegate River's watershed was originally settled about 11,000 years ago by the Latgawa, Shasta, and Dakubetede Native American tribes. The first non-indigenous settlers arrived in the early 19th century. Two boomtowns—Sterlingville and Buncom—were founded in the 1850s and grew rapidly as gold and other precious metals were discovered. They slowly declined in population as the supply of gold was exhausted; only three buildings remain in Buncom, while Sterlingville was abandoned and later destroyed.
Despite low water quality, the Little Applegate watershed supports populations of coho and Chinook salmon, along with 138 known and 134 suspected species