Publications associées à Gating (electrophysiology)

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Henry Markram, Rajnish Ranjan, Emmanuelle Logette, Enrico Scantamburlo, Mirjia Herzog, Valérie Buchillier, Michela Marani, Valérie Tâche

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

2019

High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer

Henning Paul-Julius Stahlberg

Eukaryotic cyclic nucleotide-modulated channels perform their diverse physiological roles by opening and closing their pores to ions in response to cyclic nucleotide binding. We here present a structural model for the cyclic nucleotide-modulated potassium ...

Elsevier BV2017

Mapping the function of neuronal ion channels in model and experiment

Rajnish Ranjan, Alexander Kevin Seeholzer, Tim Vogels, William Francis Podlaski

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison o ...

Elife Sciences Publications Ltd2017

Effect of Fe(II)/Fe(III) species, pH, irradiance and bacterial presence on viral inactivation in wastewater by the photo-Fenton process: Kinetic modeling and mechanistic interpretation

César Pulgarin, Michaël Bensimon, Anna Carratala Ripolles, Stefanos Giannakis, Siting Liu

Advanced Oxidation Processes and in particular photo-Fenton, represent promising strategies of pathogen inactivation in wastewater effluents. Nevertheless, its full potential is not yet unlocked, as the efficacy of photo-Fenton against viruses has not been ...

Elsevier2017

A Gating Mechanism of the Serotonin 5-HT3 Receptor

Horst Vogel, Shuguang Yuan

Our recently solved high-resolution structure of the serotonin 5-HT3 receptor (5-HT3R) delivered the first detailed structural insights for a mammalian pentameric ligand-gated ion channel. Based on this structure, we here performed a total of 2.8-μs all-at ...

Cell Press2016

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Horst Vogel, Henning Paul-Julius Stahlberg, Cédric Deluz, Luigino Grasso, Ghérici Hassaïne

The function of membrane proteins is best understood if their structure in the lipid membrane is known. Here, we determined the structure of the mouse serotonin 5-HT3 receptor inserted in lipid bilayers to a resolution of 12 Å without stabilizing antibodie ...

Elsevier2016

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Jean-Jacques Meister, Niccolo Piacentini, Franck Claude Raynaud, Jairo Camilo Quijano Perez

Vascular smooth muscle cells exhibit intercellular Ca2+ waves in response to local mechanical or KCl stimulation. Recently, a new type of intercellular Ca2+ wave was observed in vitro in a linear arrangement of smooth muscle cells. The intercellular wave w ...

Nature Publishing Group2016

Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons

Wulfram Gerstner, Skander Mensi, Christian Antonio Pozzorini, Olivier Richard Hagens

The way in which single neurons transform input into output spike trains has fundamental consequences for network coding. Theories and modeling studies based on standard Integrate-and-Fire models implicitly assume that, in response to increasingly strong i ...

Public Library of Science2016

Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins

Henning Paul-Julius Stahlberg

The chloride channel (ClC) protein family comprises both chloride (Cl-) channels and chloride/proton (Cl/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl- ions across the membrane. In eukaryotes, ClC proteins play a ...

Elsevier BV2016

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Gating (electrophysiology)

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer

Mapping the function of neuronal ion channels in model and experiment

Fluorescent sensor proteins to assess the cellular uptake of therapeutic peptides and small molecules

Effect of Fe(II)/Fe(III) species, pH, irradiance and bacterial presence on viral inactivation in wastewater by the photo-Fenton process: Kinetic modeling and mechanistic interpretation

A Gating Mechanism of the Serotonin 5-HT3 Receptor

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons

Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins

Graph Chatbot

Chattez avec Graph Search

Fluorescent sensor proteins to assess the cellular uptake of therapeutic peptides and small molecules

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer

Effect of Fe(II)/Fe(III) species, pH, irradiance and bacterial presence on viral inactivation in wastewater by the photo-Fenton process: Kinetic modeling and mechanistic interpretation

Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins

A Gating Mechanism of the Serotonin 5-HT3 Receptor

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles