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Publications associées (25)

Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol-consisting of pair ...

Elife Sciences Publications Ltd2013

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

Henry Markram, Jean-Vincent Le Bé

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Ralf Schneggenburger, Olexiy Kochubey, Heather Mary Elizabeth Murray, Heike Runne, Yunyun Han, Le Xiao

The large glutamatergic calyx of Held synapse in the auditory brainstem has become a powerful model for studying transmitter release mechanisms, but the molecular bases of presynaptic function at this synapse are not well known. Here, we have used single-c ...

2010

MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [F-18]MPPF study

Purpose Earlier studies have shown that positron emission tomography (PET) imaging with the radioligand [F-18] MPPF allows for measuring the binding potential of serotonin 5-hydroxytryptamine(1A) (5-HT1A) receptors in different regions of animal and human ...

Springer-Verlag2009

A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held

Ralf Schneggenburger, Martin Guillermo Mueller

Recent studies have suggested that transmitter release facilitation at synapses is largely mediated by presynaptic Ca2+ current facilitation, but the exact contribution of Ca2+ current facilitation has not been determined quantitatively. Here, we determine ...

2008

Imaging of G protein-coupled receptors in solid-supported planar membranes at the single molecule level

Theo Lasser, Marcel Leutenegger

Odorant receptors are an excellent example of natural superiority in binding specific, small and hydrophobic molecules, and therefore are of particular interest in the development of a sensor platform for G protein-coupled receptors (GPCRs). Odorant recept ...

2008

Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

Patrick Aebischer, Bernard Schneider

Parkinson disease (PD) is characterized by the progressive degeneration of substantia nigra dopaminergic neurons projecting to the striatum. Since the deficit in striatal dopamine is the main cause of PD symptoms, it appears critical to preserve axon termi ...

2004

A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation

Maria del Carmen Sandi Perez

The neural cell adhesion molecule (NCAM) plays a critical role in development and plasticity of the nervous system and is involved in the mechanisms of learning and memory. Here, we show that intracerebroventricular administration of the FG loop (FGL), a s ...

2004

Coding of temporal information by activity-dependent synapses

Henry Markram, Idan Segev

Synaptic transmission in the neocortex is dynamic, such that the magnitude of the postsynaptic response changes with the history of the presynaptic activity. Therefore each response carries information about the temporal structure of the preceding presynap ...

2002

Neural networks with dynamic synapses

Henry Markram

Transmission across neocortical synapses depends on the frequency of presynaptic activity (Thomson & Deuchars, 1994). Interpyramidal synapses in layer V exhibit fast depression of synaptic transmission, while other types of synapses exhibit facilitation of ...

1998

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