Concept
Gene–environment interaction
Publications associées (52)
20-years work investigating the shine-through paradigm in the schizophrenia spectrum: what is next?
Michael Herzog, Simona Adele Garobbio, Maya Roinishvili
In the past 20 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...
2023Selective elimination of enterovirus genotypes by activated sludge and chlorination
Enteroviruses, which are commonly circulating viruses shed in the stool, are released into the sewage system and only partially removed or inactivated, resulting in the discharge of infectious enteroviruses into the environment. Activated sludge and chlori ...
2023Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Pooja Jha
How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...
NATURE PORTFOLIO2021Aptamer Conformational Change Enables Serotonin Biosensing with Nanopipettes
Nako Nakatsuka, Dmitry Momotenko, Dominic Eggemann, Csaba Forro
We report artificial nanopores in the form of quartz nanopipettes with ca. 10 nm orifices functionalized with molecular recognition elements termed aptamers that reversibly recognize serotonin with high specificity and selectivity. Nanoscale confinement of ...
2021Polygenic modelling of treatment effect heterogeneity
Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking) genetic variant that can be used ...
2020