Concept
Liaison peptidique
Publications associées (157)
Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides
Christian Heinis, Alessandro Angelini, Shiyu Chen, Julia Morales Sanfrutos
Combinatorial libraries of structurally diverse peptide macrocycles offer a rich source for the development of high-affinity ligands to targets of interest. In this work we have developed linkers for the generation of genetically encoded bicyclic peptides ...
2012A Combination of Cold Ion Spectroscopy and Ion Mobility for the Study of Complex Peptides and Small Proteins
We present in this work experiments that push the limits of cold ion spectroscopy to the study of complex peptides and small proteins in the gas phase. Although the low temperature attainable in a cold ion trap greatly simplifies the electronic spectra of ...
EPFL2012Chemical macrocyclization of peptides fused to antibody Fc fragments
Christian Heinis, David Hacker, Laure Menin, Alessandro Angelini, Philippe Diderich, Julia Morales Sanfrutos, Sarah Thurnheer
To extend the plasma half-life of a bicyclic peptide antagonist, we chose to link it to the Fc fragment of the long-lived serum protein IgG1. Instead of chemically conjugating the entire bicyclic peptide, we recombinantly expressed its peptide moiety as a ...
Amer Chemical Soc2012Study of Amyloid beta-Peptide (A beta 12-28-Cys) Interactions with Congo Red and beta-Sheet Breaker Peptides Using Electrochemical Impedance Spectroscopy
Hubert Girault, Raheleh Partovi Nia
A surface-based approach is presented to study the interactions of A beta 12-28-Cys assembled on gold surfaces with Congo red (CR) and a beta-sheet breaker (BSB) peptide. The various aspects of the peptide film have been examined using different electroche ...
American Chemical Society2012Bicyclization and tethering to albumin yields long-acting Peptide antagonists
Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos
Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...
Amer Chemical Soc2012Spectroscopy of mobility-selected biomolecular ions
Thomas Rizzo, Annette Svendsen, Georgios Papadopoulos
We describe here experiments that combine differential ion mobility, which separates conformational isomers of biomolecular ions, with electronic spectroscopy in a cold, radio-frequency ion trap. Although the low temperature attainable in a cold ion trap g ...
2011Highly selective rhodium catalyzed domino C-H activation/cyclizations
The direct functionalization of carbon-hydrogen bonds is an emerging tool to establish more sustainable and efficient synthetic methods. We present its implementation in a cascade reaction that provides a rapid assembly of functionalized indanylamines from ...
Swiss Chemical Society2011Understanding Regioselective Cleavage in Peptide Hydrolysis by a Palladium(II) Aqua Complex: A Theoretical Point of View
Hydrolytic: cleavage of the oligopeptides Ace-Ala-Lys-Tyr-Gly similar to Gly-Met-Ala-Ala-Arg-Ala and Ace-Lys-Gly-Gly-Ala-Gly similar to Pro-Met-Ala-Ala-Arg-Gly by Pd(H2O)(4) was theoretically investigated by using molecular dynamics simulations and q ...
2010Supramolecular replication of peptide and DNA patterned arrays
Here we present a novel approach to the parallel fabrication of protein and protein/DNA features on surfaces. ...
2010Structure, Dynamics and Thermodynamics of the Human Centrin 2/hSfi1 Complex
Geoffrey Bodenhausen, Daniel Abergel
Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of centrosomes, and Sfi1 (Suppressor of fermentation-induced loss of stress resistance protein 1) is one of its centrosomal targets. There are three isoforms of h ...
Elsevier2010