A white-collar worker is a person who performs professional service, desk, managerial, or administrative work. White-collar work may be performed in an office or other administrative setting. White-collar workers include job paths related to government, consulting, academia, accountancy, business and executive management, customer support, design, economics, engineering, market research, finance, human resources, operations research, marketing, public relations, information technology, networking, law, healthcare, architecture, and research and development. In contrast: blue-collar workers perform manual labor and/or work in skilled trades; pink-collar workers work in care, health care, social work, or teaching; and grey-collar jobs combine manual labor and skilled trades with non-manual or managerial duties. The term refers to the white dress shirts of male office workers common through most of the nineteenth and twentieth centuries in Western countries, as opposed to the blue overalls worn by many manual laborers. The term "white collar" is credited to Upton Sinclair, an American writer, in relation to contemporary clerical, administrative, and management workers during the 1930s, though references to white-collar work appear as early as 1935. White collar employees are considered highly educated as compared to blue collar. Less physical activity among white-collar workers has been thought to be a key factor in increased life-style related health conditions such as fatigue, obesity, diabetes, hypertension, cancer, and heart disease. Also, working at a computer could potentially lead to diseases associated with monotonous data entry such as carpal tunnel syndrome. Workplace interventions such as alternative activity workstations, sit-stand desks, and promotion of stair use are among measures being implemented to counter the harms of sedentary workplace environments. The quality of evidence used to determine the effectiveness and potential health benefits of many of these interventions is weak.

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