Evolutionary ethics

Evolutionary ethics is a field of inquiry that explores how evolutionary theory might bear on our understanding of ethics or morality. The range of issues investigated by evolutionary ethics is quite broad. Supporters of evolutionary ethics have claimed that it has important implications in the fields of descriptive ethics, normative ethics, and metaethics. Descriptive evolutionary ethics consists of biological approaches to morality based on the alleged role of evolution in shaping human psychology and behavior. Such approaches may be based in scientific fields such as evolutionary psychology, sociobiology, or ethology, and seek to explain certain human moral behaviors, capacities, and tendencies in evolutionary terms. For example, the nearly universal belief that incest is morally wrong might be explained as an evolutionary adaptation that furthered human survival. Normative (or prescriptive) evolutionary ethics, by contrast, seeks not to explain moral behavior, but to justify or debunk certain normative ethical theories or claims. For instance, some proponents of normative evolutionary ethics have argued that evolutionary theory undermines certain widely held views of humans' moral superiority over other animals. Evolutionary metaethics asks how evolutionary theory bears on theories of ethical discourse, the question of whether objective moral values exist, and the possibility of objective moral knowledge. For example, some evolutionary ethicists have appealed to evolutionary theory to defend various forms of moral anti-realism (the claim, roughly, that objective moral facts do not exist) and moral skepticism. The first notable attempt to explore links between evolution and ethics was made by Charles Darwin in The Descent of Man (1871). In Chapters IV and V of that work Darwin set out to explain the origin of human morality in order to show that there was no absolute gap between man and animals. Darwin sought to show how a refined moral sense, or conscience, could have developed through a natural evolutionary process that began with social instincts rooted in our nature as social animals.

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Evolutionally dynamic control of LINE-1 elements in embryonic stem cells

Natali Pennese

Mobile elements are important evolutionary forces that challenge genomic integrity. Long interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still active in the human genome. It displays an unusual pattern of evolution, with at any given time a single active L1 lineage amplifying to thousands of copies before getting replaced by a new lineage likely under pressure of host restriction factors, which act notably by silencing L1 expression during early embryogenesis. Here, we demonstrate that in human embryonic stem cells (hESC) KAP1, the master co-factor of KRAB-containing zinc finger proteins (KRAB-ZFP) previously implicated in the restriction of endogenous retroviruses, represses a discrete subset of L1 lineages predicted to have entered the ancestral genome between 26.8 and 7.6 million years ago. In the mouse, we documented a similar chronologically conditioned pattern, albeit with a much contracted time scale. We could further identify an L1-binding KRAB-ZFP, suggesting that this rapidly evolving protein family is more globally responsible for L1 recognition. KAP1 knockdown in hESC induced the expression of KAP1-bound L1 elements, but their younger, human-specific counterparts (L1Hs) were unaffected. Instead, they were stimulated by depleting DNA methyltransferases, consistent with recent evidence demonstrating that the PIWI-piRNA pathway regulates L1Hs in hESC. Altogether, these data indicate that the early embryonic control of L1 is an evolutionary dynamic process, and support a model whereby newly emerged lineages are first suppressed by DNA methylation-inducing small RNA-based mechanisms, before KAP1-recruiting protein repressors are selected.

EPFL2015

Evolutionary ethics

Outline of ethics

Ethics or moral philosophy is a branch of philosophy that involves systematizing, defending, and recommending concepts of right and wrong conduct. The field of ethics, along with aesthetics, concern matters of value, and thus comprise the branch of philosophy called axiology. The following outline is provided as an overview of and topical guide to ethics.

Darwinisme social

Le darwinisme social est un terme englobant qui désigne toute doctrine ou théorie prétendant pouvoir appliquer la théorie évolutionniste aux sociétés humaines. Le terme apparaît pour la première fois sous la plume de l'anarchiste Émile Gautier, qui publie en 1880 Le Darwinisme social, une brochure qui entend contrer les théories qu'il baptise de ce néologisme. Le terme darwinisme social est toujours usité dans un sens polémique et négatif et n'a jamais été revendiqué ni même employé par les tenants des théories qui y sont associées.

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