Concept
Amphétamine
Publications associées (53)
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics
Camille Véronique Bernadette Goemans, Florian Huber
By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, in which initial ...
2024Shared functional connectome fingerprints following ritualistic ayahuasca intake
Enrico Amico, Hanna Tolle, Pablo Mallaroni
The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...
San Diego2023Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD
Objective: To examine whether putatively atypical neuronal activity during internal attention in ADHD yields insights into processes underlying emotion dysregulation. Methods: We used a word processing paradigm to assess neural activations in adults with A ...
2023Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function
Maria del Carmen Sandi Perez, Bernard Schneider, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Marie-Isabelle Guillot de Suduiraut, Alessandro Chioino, Sriparna Ghosal, Eva Ramos Fernandez
The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...
2023Interfacing aptamer-modified nanopipettes with neuronal media and ex vivo brain tissue
Nako Nakatsuka, Anna Burdina, Annina Stuber
Aptamer-functionalized biosensors exhibit high selectivity for monitoring neurotransmitters in complex environments. We translated nanoscale aptamer-modified nanopipette sensors to detect endogenous dopamine release in vitro and ex vivo. These sensors empl ...
2023Dopamine Transporter, PhosphoSerine129 alpha-Synuclein and alpha-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
Salvatore Novello, Chiara Domenicale
The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson's disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 alpha-synuclein (pSer129 alpha-syn ...
MDPI2022Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions
Alessandro Angelini, Alessandro Zorzi, Sara Linciano
Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting t ...
ELSEVIER2022Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity
Bernard Schneider, Akhil Sharma
Methamphetamine (METH) is a highly abused psychostimulant that is neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases the risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated ...
MDPI2022Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders
Paul Bowen, Gabrielle Anne Laguisma Sblendorio
beta-Tricalcium Phosphate (beta-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include beta-calcium pyrophosphate (beta-CPP) and hydroxyapatite (HA). Currently, the ef ...
KEAI PUBLISHING LTD2022Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort
Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, Simone Astori, João Pedro de Matos Rodrigues, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Alina Veronika Irene Strasser, Eva Ramos Fernandez
Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...
2022