Publications associées à Gliogenesis

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Ute Koch, Nadine Fournier, Jelena Zaric, Rajwinder Lehal, Linlin Cao, Michele Vigolo

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

NATL ACAD SCIENCES2020

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

Elise Marie Catherine Vinckenbosch

Magnetic resonance at ultra-high field increases signal and spectral dispersion. In this thesis, I use those characteristics to investigate three different subjects in 13C spectroscopy, hyperpolarized methods and chemical exchange saturation transfer (CEST ...

EPFL2018

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew, Zhigang He

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Notch as a tumour suppressor

Freddy Radtke, Craig Nowell

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recen ...

Nature Publishing Group2017

Delta-Notch signalling in segmentation

Andrew Charles Oates

Modular body organization is found widely across multicellular organisms, and some of them form repetitive modular structures via the process of segmentation. It's vastly interesting to understand how these regularly repeated structures are robustly genera ...

Elsevier Sci Ltd2017

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

Elizabeth Anne Allen

Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates th ...

Nature Publishing Group2015

The Notch pathway controls fibrotic and regenerative repair in the adult heart

Freddy Radtke, Mario Gaetano Lepore

Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stromal cell ...

Oxford University Press2014

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Rolf Gruetter, Lijing Xin, Bernard Lanz

Astrocytes have recently become a major center of interest in neurochemistry with the discoveries on their major role in brain energy metabolism. An interesting way to probe this glial contribution is given by in vivo 13C NMR spectroscopy coupled with the ...

Wiley-Blackwell2014

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Gliogenesis

Pharmacological disruption of the Notch transcription factor complex

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

Required growth facilitators propel axon regeneration across complete spinal cord injury

Notch as a tumour suppressor

Delta-Notch signalling in segmentation

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

The Notch pathway controls fibrotic and regenerative repair in the adult heart

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Graph Chatbot

Chattez avec Graph Search

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Delta-Notch signalling in segmentation

Required growth facilitators propel axon regeneration across complete spinal cord injury

Notch as a tumour suppressor

The Notch pathway controls fibrotic and regenerative repair in the adult heart

Pharmacological disruption of the Notch transcription factor complex

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T