Concept

Hémofiltration

Publications associées (25)

Visual masking and schizophrenia: enhancement deficit 200 ms after stimulus onset

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

Masking is strongly deteriorated in schizophrenia patients and to a lesser extent in their healthy relatives. For this reason, masking is a good endophenotype. Here, we show the EEG correlates of masking across the schizophrenia continuum in order to tackl ...

2018

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

Christian Heinis, Alessandro Zorzi, Jonas Alfred Karl Wilbs, Simon Jan Middendorp

The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' ...

2017

Electrovariable gold nanoparticle films at liquid–liquid interfaces: from redox electrocatalysis to Marangoni-shutters

Hubert Girault, Pekka Eero Peljo, Evgeny Smirnov, Grégoire Clément Gschwend

Control over the physical properties of nanoparticle assemblies at a liquid–liquid interface is a key technological advancement to realize the dream of smart electrovariable nanosystems. Electrified interfaces, such as the interface between two immiscible ...

Royal Society of Chemistry2017

Integrated Electronics to Control and Readout Electrochemical Biosensors for Implantable Applications

Seyedeh Sara Ghoreishizadeh

Biosensors can effectively be used to monitor multiple metabolites such as glucose, lactate, ATP and drugs in the human body. Continuous monitoring of these metabolites is essential for patients with chronic or critical conditions. Moreover, this can be us ...

EPFL2015

Schizophrenia and visual backward masking: a general deficit of target enhancement

Michael Herzog, Maya Roinishvili

The obvious symptoms of schizophrenia are of cognitive and psychopathological nature. However, schizophrenia affects also visual processing which becomes particularly evident when stimuli are presented for short durations and are followed by a masking stim ...

Frontiers Research Foundation2013

An implantable biosensor array for personalized therapy applications

Andrea Cavallini

At present, most of the tests involved in personalized medicine are complex and must be conducted in specialized centers. The development of appropriate, fast and inexpensive diagnostic technologies can encourage medical personnel in performing preventive ...

EPFL2013

Bicyclization and tethering to albumin yields long-acting Peptide antagonists

Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos

Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...

Amer Chemical Soc2012

Dynamic and reversible self-assembly of photoelectrochemical complexes based on lipid bilayer disks, photosynthetic reaction centers, and single-walled carbon nanotubes

Ardemis Anoush Boghossian

An aq. soln. contg. photosynthetic reaction centers (RCs), membrane scaffold proteins (MSPs), phospholipids, and single-walled carbon nanotubes (SWCNTs) solubilized with the surfactant sodium cholate (SC) reversibly self-assembles into a highly ordered str ...

2011

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Ozgün Gökce, Heike Runne

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves ...

National Academy of Sciences2010

Comparative assessment of intimal hyperplasia development after 14 days in two different experimental settings: tissue culture versus ex vivo continuous perfusion of human saphenous vein

Nikolaos Stergiopoulos, Joël Rey

Intimal hyperplasia (IH) is a vascular remodeling process which often leads to failure of arterial bypass or hemodialysis access. Experimental and clinical work have provided insight in IH development; however, further studies under precise controlled cond ...

2004

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