Concept
Puce à ADN
Publications associées (370)
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify ...
Rockefeller Univ Press2017Flexible Cylindrical Neural Probe With Graphene Enhanced Conductive Polymer For Multi-Mode Bci Applications
This paper reports a novel flexible neural probe fabricated by cylindrical substrates lithography for Brain-Computer-Interface (BCI) applications. The electrode sites were patterned on the cylindrical surface to acquire high space selectivity and the micro ...
Ieee2017The effects of mitochondrial- and histone stress on the C. elegans transcriptome
Johan Auwerx, Maroun Bou Sleiman
The aim of this study was to explore whether mitochondrial- and histone stress cause any common changes in global gene expression. For this experiment, we performed RNA sequencing from control RNAi, cco-1 RNAi (mitochondrial stress) and his-3 RNAi (histone ...
EPFL Infoscience2017Batch Mode TD(lambda) for Controlling Partially Observable Gene Regulatory Networks
External control of gene regulatory networks (GRNs) has received much attention in recent years. The aim is to find a series of actions to apply to a gene regulation system making it avoid its diseased states. In this work, we propose a novel method for co ...
2017Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes
Nicola Harris, Benjamin John Marsland, Alexis Rapin, Céline Pattaroni
The microbiota have been shown to play an important role in diverse biological processes including immunity, metabolism, and digestion. Assessing the exact composition of the microbiota has proven challenging due to the often unknown growth specificities o ...
2017NMR spectroscopy of single sub-nL ova with inductive ultra-compact single-chip probes
Giovanni Boero, Franck Vincent, Marco Grisi, Nicola Harris, Beatrice Volpe
Nuclear magnetic resonance (NMR) spectroscopy enables non-invasive chemical studies of intact living matter. However, the use of NMR at the volume scale typical of microorganisms is hindered by sensitivity limitations, and experiments on single intact orga ...
2017Comparative study of joint analysis of microarray gene expression data in survival prediction and risk assessment of breast cancer patients
Microarray gene expression data sets are jointly analyzed to increase statistical power. They could either be merged together or analyzed by meta-analysis. For a given ensemble of data sets, it cannot be foreseen which of these paradigms, merging or meta-a ...
Oxford Univ Press2016Discrimination of oligonucleotides of different lengths with a wild-type aerolysin nanopore
Protein nanopores offer an inexpensive, label-free method of analysing single oligonucleotides. The sensitivity of the approach is largely determined by the characteristics of the pore-forming protein employed, and typically relies on nanopores that have b ...
2016Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction
Yohan Van de Looij, Maxime Olivier Baud
Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms link ...
Wiley-Blackwell2016Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering
The research described within this thesis is primarily motivated by two fields of science with reversed, yet complementary, approaches to addressing the same essential objective: manipulating and understanding the complex program of life. Whereas synthetic ...
EPFL2016