Concept

Intrinsically photosensitive retinal ganglion cell

Publications associées (154)

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedb ...

2012

X-ray tomographic microscopy analysis of the dendrite orientation transition in Al-Zn

Michel Rappaz, Jonathan Friedli, Paolo Di Napoli

Recently, Gonzales and Rappaz [Met. Mat. Trans. A37:2797, 2006] showed the influence of an increasing zinc content on the growth directions of aluminum dendrites. < 100 > and < 110 > dendrites were observed below 25wt.% and above 55wt.% zinc, respectively, ...

Iop Publishing Ltd2012

Principles Governing the Operation of Synaptic Inhibition in Dendrites

Idan Segev

Synaptic inhibition plays a key role in shaping the dynamics of neuronal networks and selecting cell assemblies. Typically, an inhibitory axon contacts a particular dendritic subdomain of its target neuron, where it often makes 10–20 synapses, sometimes on ...

2012

Simulations to study spatial extent of stimulation and effect of electrode–tissue gap in subretinal implants

Philippe Renaud, Arnaud Bertsch, Sri Harsha Kasi Raj

We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode–tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to ...

Elsevier2011

Analysis of Factors Affecting the Performance of Retinal Prostheses Using Finite Element Modelling of Electric Field Distribution in the Retina

Sri Harsha Kasi Raj

This dissertation proposes a computational framework targeted at improving the design of currently employed retinal prostheses. The framework was used for analysing factors impacting the performance of prostheses in terms of electrical stimulation for reti ...

EPFL2011

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Pascal Escher

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors. The nucle ...

Public Library of Science2011

Altered Expression of the Transcription Factor Mef2c during Retinal Degeneration in Rpe65(-/-) Mice

Pascal Escher

PURPOSE. To investigate the role of the myocyte enhancer factor 2 (Mef2) transcription factor family in retinal diseases, Mef2c expression was assessed during retinal degeneration in the Rpe65(-/-) mouse model of Leber's congenital amaurosis (LCA). Mef2c-d ...

2011

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

Pierre Gönczy, Petr Strnad, Debora Keller, Fernando Romero Balestra, Gregor Kohlmaier

Patients with MCPH (autosomal recessive primary microcephaly) exhibit impaired brain development, presumably due to the compromised function of neuronal progenitors. Seven MCPH loci have been identified, including one that encodes centrosome protein 4.1 as ...

Company of Biologists2011

Simulation of epiretinal prostheses - Evaluation of geometrical factors affecting stimulation thresholds

Philippe Renaud, Arnaud Bertsch, Willyan Hasenkamp Carreira, Sri Harsha Kasi Raj, Grégoire Cosendai

Background An accurate understanding of the electrical interaction between retinal prostheses and retinal tissue is important to design effective devices. Previous studies have used modelling approaches to simulate electric fields generated by epiretinal p ...

BioMed Central2011

Climate-based Daylight Performance: Balancing Visual and Non-visual Aspects of Light Input

Marilyne Andersen, Nicolas Roy

This study uses a domestic dwelling as the setting to investigate and explore the applicability of daylighting metrics for residential buildings, including the formulation of metrics for nonvisual effects. The simulation approach used to generate the perfo ...

2011

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