Concept
Glutamine synthétase
Publications associées (34)
A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3
There is increasing evidence for vesicular release of glutamate from astrocytes. We have previously demonstrated existence of VGLUT1 on astrocytic synaptic-like microvesicles (SMLVs) in several brain regions indicating a role in astroglial glutamate releas ...
2012Simultaneous neurochemical stimulation and recording using an assembly of biosensor silicon microprobes and SU-8 microinjectors
Nico de Rooij, Peter Van der Wal, Olivier Frey
In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process for the local delivery of specific substances into brain tissue. They are designed to be assembled with previously developed. implantable b ...
Elsevier2011Effect of manganese chloride on the neurochemical profile of the rat hypothalamus
Rolf Gruetter, Cristina Ramona Cudalbu, Hongxia Lei, Nathalie Just
Manganese (Mn 2+)-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food intake and energy balance circulate through specific hypothalamic nuclei. The dehydration-induce ...
Nature Publishing Group2011Glial Energy Metabolism: A NMR Spectroscopy Perspective
Oxygen metabolism is uniquely compartmentalized between neurons and glia, the latter comprising about 25% of neuronal energy metabolism. The consumption of acetate and fixation of CO2 in glutamine occur in astrocytes by oxygen-dependent reactions, which po ...
Elsevier2009In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role in these impairments. To understand the ...
Elsevier2005Evaluation of brain mitochondrial glutamate and alpha-ketoglutarate transport under physiologic conditions
Some models of brain energy metabolism used to interpret in vivo (13)C nuclear magnetic resonance spectroscopic data assume that intramitochondrial alpha-ketoglutarate is in rapid isotopic equilibrium with total brain glutamate, most of which is cytosolic. ...
Wiley-Blackwell2005Localized in vivo 13C NMR spectroscopy of the brain
Localized (13)C NMR spectroscopy provides a new investigative tool for studying cerebral metabolism. The application of (13)C NMR spectroscopy to living intact humans and animals presents the investigator with a number of unique challenges. This review pro ...
Wiley-Blackwell20031H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 T
Localized (13)C NMR spectra were obtained from the rat brain in vivo over a broad spectral range (15-100 ppm) with minimal chemical-shift displacement error (
Wiley-Blackwell2003Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action
The effect of deep barbiturate anesthesia on brain glucose transport, TCA cycle flux, and aspartate, glutamate, and glutamine metabolism was assessed in the rat brain using 13C nuclear magnetic resonance spectroscopy at 9.4 T in conjunction with [1-13C] gl ...
Nature Publishing Group2002In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism
Localized 13C nuclear magnetic resonance (NMR) spectroscopy provides a unique window for studying cerebral carbohydrate metabolism through, e.g. the completely non-invasive measurement of cerebral glucose and glycogen metabolism. In addition, label incorpo ...
Elsevier2002