Concept

Cancer de l'estomac

Publications associées (84)

Interleukin 2 immune response generating formulation, used for treating cancer, comprises IL 2 coupled to transport protein, monoclonal anti IL 2 antibody or monoclonal anti CD 25 antibody

NOVELTY - A formulation comprising one or more components chosen from interleukin (IL)-2 or a derivative thereof coupled to a transport protein, a monoclonal anti-IL-2 antibody, a cancer vaccine based on specific antigens of tumors or tumor growth factors ...

2006

Heterogeneity in multistage carcinogenesis and mixture modeling

Sandro Gsteiger

Carcinogenesis is commonly described as a multistage process. In a first step, a stem cell is transformed via a series of mutations into an intermediate cell having a growth advantage. Under favorable conditions, such a cell will give rise to a clone of in ...

EPFL2006

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

Johan Auwerx, Kristina Schoonjans

Liver receptor homolog 1 (LRH-1) is an orphan nuclear receptor that synergizes with beta-catenin/T cell factor 4 signaling to stimulate intestinal crypt cell renewal. We evaluated here the impact of haploinsufficiency of LRH-1 on intestinal tumorigenesis b ...

2005

Optimalisation de la photothérapie dynamique et de la photodétection de cancers précoces par spectroscopie résolue en temps de luminophores endogènes et exogènes

Pascal Uehlinger

The aim of this thesis is to optimize and obtain fundamental information on i) the photodetection (PD) of early stage cancers in the tracheo-bronchial tree by spectroscopic imaging of the tissue autofluorescence, ii) photodynamic therapy (PDT) applied in d ...

EPFL2004

Optical spectral probing for epithelial tissue characterisation

Philippe Thueler

In this thesis, a new method has been developed, which determines the optical coefficients spectra (absorption and scattering) of small volumes of tissue (1 mm3) by the measurement of spatially resolved reflectance between 480 and 950 nm. Firstly, an algor ...

EPFL2001

Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems

Paul Joseph Dyson, Claire Samantha Allardyce

Proteins from cisplatin treated bacterial cells were partially separated by 1D polyacrylamide gel electrophoresis and analysed by laser ablation inductively coupled plasma mass spectrometry; using peptide fingerprinting methods central to proteomics, the b ...

2001

A highly selective telomerase inhibitor limiting human cancer cell proliferation

Joachim Lingner

Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is active in most human cancers and in germline cells but, with few exceptions, not in normal human somatic tissues. Telomere maintenance is essential to the repl ...

2001

Time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin and benzoporphyrin derivative monoacid ring A in the hamster model: comparative fluorescence microscopy study

Hubert van den Bergh, Georges Wagnières

The pharmacokinetics of the photosensitizer used play a key role in the understanding of the mechanism of photodynamic therapy-induced damage. Fluorescence microscopy was used to compare time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin (mTHP ...

2000

Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) with Foscan (mTHPC) is used to cure early cancers of the esophagus or the tracheobronchial tree. However, fixed PDT parameters (drug dose, light dose, etc.) do not permit an accurate prediction of the tissue damage. Large interpa ...

1999

Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer

Hubert van den Bergh, Georges Wagnières

The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to the bladder tumor multiplicity and the presence of concomitant 'plane' tumors such as high grade dysplasia and carcinoma in situ (CIS). This study on 3 ...

1997

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