Publications associées à Réseau métabolique

Identification of Feasible Metabolic Fluxes and Metabolite Concentrations using Large-scale Kinetic Models

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti

The constraints imposed during modeling must satisfy biologically representative phenotypes of the studied organism. Simultaneously, identification and analysis of these constraints enhances our understanding of the evolution/operational paradigms of the o ...

2013

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiology constraints

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti

Mathematical modeling is an essential tool for a comprehensive understanding of cell metabolism and its interactions with the environmental and process conditions. Recent developments in the construction and analysis of stoichiometric models made it possib ...

2013

In silico analysis of the interplay between P/O ratio and physiological states of the optimally grown Escherichia coli

Ljubisa Miskovic, Meriç Ataman, Keng Cher Soh, Stefano Andreozzi

The bioenergetics efficiency of aerobic respiration of an organism is expressed through P/O ratio, which represents the ATP production per oxygen atom reduced in Electron Transport Chains (ETC). P/O ratio, to date, has not been extensively used in the cont ...

2013

Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

Kinetic models of metabolic networks are mapping the biochemical reactions taking part in a cell to a mathematical representation. They are the blueprints of the biochemical network, connecting enzymatic activities and metabolic compounds. Kinetic models h ...

2013

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Rolf Gruetter, Bernard Lanz, João Miguel das Neves Duarte

Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way. Beside the measurement of the total ...

2013

Unlocking Yeast Metabolism: Identification of optimal flux directionalities

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Anirikh Chakrabarti

Metabolic modeling has proven to be a valuable tool in the investigation of cellular physiology, especially in the post-genomic era. However, the sheer complexity of even the simplest metabolic networks obstructs the exact determination of intracellular st ...

2013

Highly Dynamic Cellular-Level Response of Symbiotic Coral to a Sudden Increase in Environmental Nitrogen

Anders Meibom, Duncan Thomas Lindsay Alexander, Isabelle Domart-Coulon, Christophe Kopp

Metabolic interactions with endosymbiotic photosynthetic dinoflagellate Symbiodinium spp. are fundamental to reef-building corals (Scleractinia) thriving in nutrient-poor tropical seas. Yet, detailed understanding at the single-cell level of nutrient assim ...

American Society for Microbiology2013

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

Wiley-Blackwell2013

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Réseau métabolique

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

Identification of Feasible Metabolic Fluxes and Metabolite Concentrations using Large-scale Kinetic Models

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiology constraints

In silico analysis of the interplay between P/O ratio and physiological states of the optimally grown Escherichia coli

Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Computational Studies on Cellular Bioenergetics

Unlocking Yeast Metabolism: Identification of optimal flux directionalities

Highly Dynamic Cellular-Level Response of Symbiotic Coral to a Sudden Increase in Environmental Nitrogen

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Graph Chatbot

Chattez avec Graph Search

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Towards kinetic modeling of genome-scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiology constraints

Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data

Computational Studies on Cellular Bioenergetics

In silico analysis of the interplay between P/O ratio and physiological states of the optimally grown Escherichia coli

Metabolic modeling and experimental studies on carbon and energy metabolism of Mycobacterium tuberculosis

Identification of Feasible Metabolic Fluxes and Metabolite Concentrations using Large-scale Kinetic Models

Unlocking Yeast Metabolism: Identification of optimal flux directionalities

Highly Dynamic Cellular-Level Response of Symbiotic Coral to a Sudden Increase in Environmental Nitrogen