Concept

Réseau métabolique

Publications associées (222)

Analysis of yeast metabolism using metabolic control analysis under uncertainty

Advancement of genomic research and anal. techniques enables an in-depth understanding of individual components in the cellular metab. The crit. subject is the integration of massive exptl. details and the quantification of the contributions of individual ...

2005

How reliable are thermodynamic feasibility statements of biochemical pathways?

Urs von Stockar

The driving force for organo- or lithotrophic growth as well as for each step in the metabolic network is the Gibbs reaction energy. For each enzymic step it must be neg. Thermodn. contributes therefore to the in-silico description of living systems. It ma ...

2005

Carbon metabolism of intracellular bacteria

John McKinney

Bacterial metabolism has been studied intensively since the first observations of these 'animalcules' by Leeuwenhoek and their isolation in pure cultures by Pasteur. Metabolic studies have traditionally focused on a small number of model organisms, primari ...

2005

Metabolic control analysis under uncertainty: Framework development and case studies

Vassily Hatzimanikatis

Information about the enzyme kinetics in a metabolic network will enable understanding of the function of the network and quant. prediction of the network responses to genetic and environmental perturbations. Despite recent advances in exptl. techniques, s ...

2004

Metabolic networks: enzyme function and metabolite structure

Vassily Hatzimanikatis

A review and discussion. Metab. is one of the most complex cellular processes. Connections between biochem. reactions via substrate and product metabolites create complex metabolic networks that may be analyzed using network theory, stoichiometric anal., a ...

2004

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

Johan Auwerx

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a prototypical member of the nuclear receptor superfamily and integrates the control of energy, lipid, and glucose homeostasis. PPARgamma can bind a variety of small lipophilic compounds d ...

2004

Computational discovery of biochemical routes to specialty chemicals

Vassily Hatzimanikatis

A computational framework has been developed for the construction and evaluation of metabolic pathways given input substrates and knowledge of enzyme-catalyzed reactions. Application of the framework creates new and existing routes to both chems. known to ...

2004

Nuclear receptors and the control of metabolism

Johan Auwerx

The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to environmental changes by inducing the appropriate metabolic genes and pathways. Ligands for these metabolic receptors are compounds from d ...

2003

Quantification and characterization of uncertainty in metabolic engineering

Vassily Hatzimanikatis

One of the central problems in metabolic engineering deals with the identification of the "rate limiting steps", i.e. enzymes whose activities one should manipulate towards the achievement of a desirable performance. However, uncertainty about the kinetic ...

2003

Chemically resolved imaging of biological cells and thin films by infrared scanning near-field optical microscopy

Giorgio Margaritondo

The infrared (IR) absorption of a biological system can potentially report on fundamentally important microchemical properties. For example, molecular IR profiles are known to change during increases in metabolic flux, protein phosphorylation, or proteolyt ...

2003

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search