Concept

Réseau métabolique

Publications associées (222)

Fast Adaptive Uniformization for the Chemical Master Equation

Maria-Emanuela-Canini Mateescu, Verena Wolf

Within systems biology there is an increasing interest in the stochastic behavior of biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous-time Markov chain (CTMC). S ...

Ieee Computer Soc Press, Customer Service Center, Po Box 3014, 10662 Los Vaqueros Circle, Los Alamitos, Ca 90720-1264 Usa2009

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki

The NAD(+)-dependent deacetylase SIRT1 controls metabolic processes in response to low nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action ...

2008

Enzyme States Allow Identification of Rate-Limiting Steps

Vassily Hatzimanikatis, Ljubisa Miskovic

A precise quantification of the effect of perturbations in a metabolic network depends on explicit knowledge of the kinetic properties of the enzymes of the individual reactions. However, a comprehensive knowledge of enzymes kinetics in a metabolic network ...

2008

Plate for matrix-assisted laser desorption ionization mass spectrometry for, e.g. analyzing peptide, has substrate that is covered with light sensitive matrix with light absorber, charge carrier, probe molecule and photo-sensitizer

Hubert Girault, Niels Erik Lion, Christophe Roussel, Liang Qiao

NOVELTY - The plate has electrically conductive substrate (1) that is covered with light sensitive matrix (2). The matrix comprises light absorber, charge carrier, probe molecule and photo-sensitizer (3) arranged to oxidize probe molecule by irradiation of ...

2008

Aerobic granular sludge formation and performance at 30 and 35°C in sequencing batch bubble-column reactors

Christof Holliger, Graciela Gonzalez Gil, Sirous Ebrahimi, Sébastien Gabus, Maryam Hosseini

Aerobic granular sludge-based reactors represent an attractive alternative to conventional activated sludge systems due to their small footprint and their low energy consumption and excess sludge production. The granules developed in such systems have high ...

2008

The Age of Analog Networks

Dario Floreano, Claudio Mattiussi, Daniel Marbach, Peter Dürr

A large class of systems of biological and technological relevance can be described as analog networks, that is, collections of dynamical devices interconnected by links of varying strength. Some examples of analog networks are genetic regulatory networks, ...

2008

Multiscale modelling of metabolism and transport phenomena in living tissues

Carlo D'Angelo

The range of applications of mathematical modelling in biosciences has recently expanded to encompass problems posed by biomedicine and sport sciences. Topics of interest are for instance the prediction of the response of an athlete to exercise, the pharma ...

EPFL2007

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

Pierre Magistretti, Jean-Yves Chatton

This study examines the role of glucose and lactate as energy substrates to sustain synaptic vesicle cycling. Synaptic vesicle turnover was assessed in a quantitative manner by fluorescence microscopy in primary cultures of mouse cortical neurons. An elect ...

Elsevier2006

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

Rolf Gruetter

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. T ...

2006

Metabolic engineering under uncertainty-II: Analysis of yeast metabolism

Vassily Hatzimanikatis

Yeast metab. has been used extensively in scientific investigations and industrial applications. Understanding the properties of the yeast metabolic network is crucial, yet unaccomplished due to its high complexity, the different culture conditions, and th ...

2006

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