Concept

Adénocarcinome pulmonaire

Publications associées (32)

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Rolf Gruetter, Anders Meibom, Graham Knott, Bernard Lanz, Stéphane Laurent Escrig, Nadine Fournier, Mario Gaetano Lepore, Etienne Meylan, Louise Helene Soegaard Jensen, Inti Zlobec, Caroline Anne-Lyse Contat, Justine Pascual, Pierre-Benoit Bernard Ancey, Anouk Rossier, Silvia Sabatino

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

2020

Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness

Adrien Raphaël Depeursinge

We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule ma ...

2019

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

Filipe Amândio Brandão Sanches Vong Martins, Olivier Michielin

Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4 (CTLA-4), anti-programmed cell death 1 (PD-1) and anti-programmed cell death 1 ligand 1 (PD-L1) antibodies, are arguably the most important development in cancer therapy o ...

NATURE PUBLISHING GROUP2019

Anti-angiogenic immunotherapy for lung cancer

Ece Kadioglu

Lung cancer is the leading cause of cancer-associated deaths worldwide. Platinum-based chemotherapy is the most common therapeutic approach in advanced non-small cell lung cancer (NSCLC), particularly for tumors that carry non-druggable activating mutation ...

EPFL2019

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma

Nadine Fournier, Etienne Meylan, Julien Robert Rémi Faget, Caroline Anne-Lyse Contat

INTRODUCTION: NSCLC is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. M ...

2018

Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma

Diego Gabriel Dupouy, Benjamin Pelz, Saska Brajkovic

BackgroundAnaplastic lymphoma kinase (ALK) is a key oncogenic driver in lung adenocarcinoma patients and its fusion proteins are routinely assessed. The microfluidic tissue processor (MTP) device is based on a chip-confined low-volume technology allowing f ...

BMC2018

Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells

Nadine Fournier, Etienne Meylan, Julien Robert Rémi Faget, Svenja Johanna Groeneveld

The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promoti ...

2018

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Paolo Angelino, Etienne Meylan, Mauro Delorenzi, Alessandra Piersigilli, Jawahar Kopparam, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Nadine Fournier, Miguel Garcia, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Inti Zlobec, Gael Luis Boivin, Svenja Johanna Groeneveld, Loïc Steiner, Ioannis Xenarios

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

Role of RIP4 in lung adenocarcinoma differentiation

Jawahar Kopparam

Various studies have attributed NF-kB activation to promote KRAS mediated non-small cell lung cancer progression. In order to identify key genes regulating NF-kB activation and cell survival in lung adenocarcinoma, a synthetic lethal partner screen for KRA ...

EPFL2016

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