Concept

Neuromuscular-blocking drug

Publications associées (34)

Cell Uptake and Trafficking Behavior of Non-covalent, Coiled-coil Based Polymer-Drug Conjugates

This paper reports on the cell uptake and trafficking properties of a series of non-covalent polymer-drug conjugates. These nanomedicines are composed of a poly(N-(2-hydroxypropyl)methacrylamide) backbone functionalized with multiple copies of a drug. The ...

Wiley-Blackwell2011

Collapsin response médiator protein 4a(CRMP 4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron death

Patrick Aebischer, Nathalie Marie Géraldine Bernard

Embryonic motoneurons from mutant SOD1 (mSOD1) mouse models of amyotrophic lateral sclerosis (ALS), but not wild-type motoneurons, can be triggered to die by exposure to nitric oxide (NO), leading to activation of a motoneuron-specific signaling pathway do ...

2010

A novel verticalized reeducation device for spinal cord injuries, the WalkTrainer: from design to the clinical trials

Reymond Clavel, Mohamed Bouri, Yves Stauffer, Jacques Fournier, Yves Allemand

Robotic assistive devices have been developed and are now being introduced in clinical environments. Such robots can advantageously provide long raining, with quantifiable mobilization (force and position). But in the event of a complete lesion the patient ...

Intech publishing2010

Auditory stimulation does not induce implicit memory during anaesthesia

Michael Herzog, Alain Farron, Elisa Tartaglia, Carl Kristoffer Aberg

Background and aim of the study: Formation of implicit memory during general anaesthesia is still debated. Perceptual learning is the ability to learn to perceive. In this study, an auditory perceptual learning paradigm, using frequency discrimination, was ...

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2009

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

Patrick Aebischer

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle, leading to paralysis. In order to maintain muscle connections in a rat model of familial ALS (FA ...

2008

Co-existence of H1 and H2 histaminergic receptors in individual neurons of rat hypothalamic ventromedial nucleus (VMN)

Christophe Dupré

Histamine is a ubiquitous brain neurotransmitter. Estrogen hormones have been shown to increase histamine effects on neurons located in the ventromedial nucleus of the hypothalamus (VMN) (Kow et al, 2005a). This study has been set up to find candidate path ...

2008

Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy

Giovanni De Micheli, Sandro Carrara, Jacopo Olivo, Luca Benini, Andrea Cavallini

Drug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitori ...

IEEE2008

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

Patrick Aebischer

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by rapid loss of muscle control and eventual paralysis due to the death of large motor neurons in the brain and spinal cord. Growth factors such ...

Public Library of Science2007

Reversible sequential-binding probe receptor-ligand interactions in single cells

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

With the reversible sequential (ReSeq) binding assay, we present a novel approach for the ultrasensitive profiling of receptor function in single living cells. This assay is based on the repetitive application of fluorescent ligands that have fast assocn.- ...

2005

Interactions of highly charged polyelectrolytes with monolayers of oppositely charged amphiphiles

Jutta Christine Wandrey, Vesela Malinova

Poly(vinylbenzylammonium chloride) (PVBAC) polyelectrolytes possessing defined chain lengths, narrow chain length distributions, uniform charge d., but substituents of different hydrophilicity and size at the quaternary ammonium group were used as model co ...

2004

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