Publications associées à Antidépresseur tétracyclique

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Rolf Gruetter, Maria del Carmen Sandi Perez, Jocelin Grosse, João Pedro de Matos Rodrigues, Antoine Timothée Cherix, Thomas Didier Larrieu

Emerging evidence suggests that hierarchical status provide vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related to hierarchical status and vulnerability to develop depression-lik ...

2020

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Douglas Hanahan, Ksenya Shchors, Aristea Massaras

The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and elevated autophagy in glioma cells motivated investigation in mouse models of gliomagenesis. First, we established that imipramine, a TCA, increased autophagy and co ...

Elsevier2015

Synthetic Study towards Strictamine: The Oxidative Coupling Approach

Qian Wang, Jieping Zhu, Weiwu Ren, Nicholas David Charles Tappin

A synthetic approach featuring a key intramolecular oxidative coupling of a dianion for the formation of the C7–C16 bond was exploited aiming at the synthesis of strictamine. Treatment of substituted tetrahydrocarboline with LHMDS at –78 °C followed by iod ...

Georg Thieme Verlag Kg2013

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Pierre Magistretti, Jean-Luc Martin, Igor Allaman

There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of ...

Bentham Science Publishers2013

Psychobiological Vulnerability to Stress

Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes

Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...

EPFL2012

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier, Cristina Marquez Vega, Jorge Eduardo Castro Cifuentes

The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (B ...

Public Library of Science2010

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Maria del Carmen Sandi Perez, Reto Bisaz

Critical interactions between genetic and environmental factors -- among which stress is one of the most potent non-genomic factors -- are involved in the development of mood disorders. Intensive work during the past decade has led to the proposal of the n ...

Karger2007

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Antidépresseur tétracyclique

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Synthetic Study towards Strictamine: The Oxidative Coupling Approach

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Psychobiological Vulnerability to Stress

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Graph Chatbot

Chattez avec Graph Search

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Synthetic Study towards Strictamine: The Oxidative Coupling Approach

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

Psychobiological Vulnerability to Stress