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Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl h ...
The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C ...
The present invention concerns an intermediate of the following formula (I) in which R1 and R2 represent independently of each other a C1-C12 alkyl group, a (C1-C12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C2-C12 ...
The C-13 CPMAS spectrum is presented for the polymorph of oxybuprocaine hydrochloride which is stable at room temperature, i.e. Mod. II degrees. It shows crystallographic splittings arising from the fact that there are two molecules, with substantially dif ...
Methyl tertiary hexyl ether (MtHxE) and methyl tertiary octyl ether (MtOcE) are currently being developed as replacement oxygenates for methyl tertiary butyl ether (MtBE) in gasoline. As was the case with MtBE, the introduction of these ethers into fuel su ...
Non-activated alkyl halides are challenging substrates for cross-coupling reactions because they are reluctant to undergo oxidative addition and because metal alkyl intermediates are prone to β-H elimination. Despite recent progress, well-defined catalysts ...
Alkylation of alpha -isocyanoacetamide with alkyl halide in MeCN at 0 DegC in the presence of cesium hydroxide afforded the mono-alkylated product in good to excellent yield. [on SciFinder (R)] ...
The cationic complexes [(η6-arene)Ru(SC5H4NH)3]2+, arene being C6H6 (1), MeC6H5 (2), p-iPrC6H4Me (3) or C6Me6 (4), have been synthesized from the reaction of 4-pyridinethiol with the corresponding precursor (η6-arene)2Ru2(μ2-Cl)2Cl2 and isolated as the chl ...
A nickel(II) pincer complex [(MeNN2)NiCl] (1) catalyzes Kumada−Corriu−Tamao cross coupling of nonactivated alkyl halides with aryl and heteroaryl Grignard reagents. The coupling of octyl bromide with phenylmagnesium chloride was used as a test reaction. Us ...
