Concept

Médicament générique

Publications associées (43)

Screening Europe 2010: an update about the latest technologies and applications in high-throughput screening

This article reviews important presentations from the 7th Screening Europe Conference, and extracts general trends and developments. Technological advances, as well as novel applications are discussed, thus providing an overview on state-of-the-art high-th ...

2014

A generic strategy for pharmacological caging of growth factors for tissue engineering

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

The caging of small molecules has revolutionized biological research by providing a means to regulate a wide range of processes. Here we report on a generic pharmacological method to cage proteins in a similar fashion. The present approach is of value in b ...

2013

From natural product to marketed drug: the tiacumicin odyssey

Jieping Zhu

The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...

Royal Soc Chemistry2013

Investigating the acoustic release of doxorubicin from targeted micelles

Jeffrey Alan Hubbell

The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side ...

Elsevier2013

NR2C-New Road Construction Concepts. Towards reliable, green, safe&smart and human infrastructure in Europe. Part A: From the vision to developments required.

Nicolas Bueche

Today, a world without roads, cars, motorcycles and bicycles is almost unimaginable. The entire road infrastructure with its diversity of transport concepts now has a prominent − almost dominant – position in our society. The question is therefore not so m ...

2008

Fast spin +-2 spherical harmonics transforms and application in cosmology

Pierre Vandergheynst, Yves Wiaux, Laurent Jacques

A fast and exact algorithm is developed for the spin +-2 spherical harmonics transforms on equi-angular pixelizations on the sphere. It is based on the Driscoll and Healy fast scalar spherical harmonics transform. The theoretical exactness of the transform ...

2007

Determining a receptor-ligand interaction useful in e.g. drug screening involves repetitive application of reversibly binding fluorescent ligands with fast association-dissociation kinetics

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

NOVELTY - Determining a receptor-ligand interaction involves repeatedly contacting a cell comprising a receptor, with a ligand, of the receptor in which the ligand has a fluorescence labeling group and binds reversibly to the receptor under conditions in w ...

2006

Multidimensional pharmacokinetic models applied to the design of drug-eluting stents

Paolo Zunino

Drug-eluting stents are cardiovascular stents able to release a medical drug after implantation. The medical drug is, in general, aimed at healing the vascular tissues injured after implantation and to prevent restenosis. In spite of their apparent simplic ...

2004

JAGR: an autonomous self-recovering application server

George Candea

This paper demonstrates that the dependability of generic, evolving J2EE applications can be enhanced through a combination of a few recovery-oriented techniques. Our goal is to reduce downtime by automatically and efficiently recovering from a broad class ...

2003

Low cost duration modelling for noise robust speech recognition

Hervé Bourlard

State transition matrices as used in standard HMM decoders have two widely perceived limitations. One is that the implicit Geometric state duration distributions which they model do not accurately reflect true duration distributions. The other is that they ...

2002

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