Concept

Ingénierie tissulaire

Publications associées (755)

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Mechanical Reinforcement of Hydrogels through Physical Crosslinks and Double Network Granular Architecture

Alvaro Lino Boris Charlet

Throughout nature, organisms fabricate a myriad of materials to sustain their lifestyle. Many of the soft materials are composed of water-swollen networks of organic molecules, so-called hydrogels. They generally contribute to the mechanical integrity of t ...

EPFL2022

Stretchable High Response Piezoelectric Elastomers Based on Polable Polynorbornene Fillers in a Polydimethylsiloxane Matrix

Francis Owusu

To advance the field of piezoelectrics, it is desirable to find materials that combine high piezoelectricity with high elasticity. Applications such as self-sensors, stretchable electronics, soft robots, and energy harvesting would benefit tremendously. Ho ...

WILEY-V C H VERLAG GMBH2022

Actuated 3D microgels for single cell mechanobiology

Mahmut Selman Sakar, Ece Özelçi, Berna Ayse Özkale Edelmann, Christina Myra Tringides

We present a new cell culture technology for large-scale mechanobiology studies capable of generating and applying optically controlled uniform compression on single cells in 3D. Mesenchymal stem cells (MSCs) are individually encapsulated inside an optical ...

ROYAL SOC CHEMISTRY2022

An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates

Matthias Lütolf, Sebastian Maerkl, Hao-An Hsiung, Zoe Newell Swank, Stefano Davide Vianello, Julia Tischler

We present a low-cost, do-it-yourself system for complexmammalian cell culture under dynamically changing medium formulations by integrating conventional multi-well tissue culture plates with simple microfluidic control and system automation. We demonstrat ...

2022

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

Self-organized patterning of cell morphology via mechanosensitive feedback

Marko Popovic

Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tiss ...

ELIFE SCIENCES PUBLICATIONS LTD2021

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

2021

Mechanical principles of engineering fibrous tissues with programmable shape

Erik Mailand

The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...

EPFL2021

Embryonic tissues as active foams

Sangwoo Kim

The physical state of embryonic tissues emerges from non-equilibrium, collective interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics of glassy dynamics have all been observed in multicellular systems, but it is ...

2021

Engineering next generation organoids through guided stem cell self-organisation

Mikhail Nikolaev

One of the long-standing goals in the field of tissue engineering is the fabrication of de novo tissues or even organs to provide better tissue models for basic research and drug discovery, and to alleviate a shortage of donor organs in the future. Resear ...

EPFL2021