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Publications associées (19)

Flow simulation and hemolysis modeling for a blood centrifuge device

Mark Sawley, Michel Deville, Patric Hagmann

A common blood separation technique is to accelerate the sedimentation of blood constituents by centrifugation and then collect these constituents separately. When subjected to conditions of excessive stress, hemolysis can however occur, whereby the membra ...

Pergamon-Elsevier Science Ltd2013

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Jeffrey Alan Hubbell, Stephane Kontos, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering

Pierre Magistretti, Dimitri Nestor Alice Van De Ville, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Daniel Boss, Annick Hoffmann

Red blood cells (RBCs) present unique reversible shape deformability, essential for both function and survival, resulting notably in cell membrane fluctuations (CMF). These CMF have been subject of many studies in order to obtain a better understanding of ...

Public Library Science2012

Automated statistical quantification of three-dimensional morphology and mean corpuscular hemoglobin of multiple red blood cells

Pierre Marquet, Daniel Boss

In this paper, we present an automated approach to quantify information about three-dimensional (3D) morphology, hemoglobin content and density of mature red blood cells (RBCs) using off-axis digital holographic microscopy (DHM) and statistical algorithms. ...

Optical Society of America2012

Microelectrode-based dielectric spectroscopy of glucose effect on erythrocytes

Philippe Renaud, Ludovica Colella

The dielectric response of biconcave erythrocytes exposed to D-glucose and I.-glucose has been investigated using a double array of planar interdigitated microelectrodes on a glass microchip. Erythrocytes are analyzed under physiological conditions suspend ...

2012

Recognition and classification of red blood cells using digital holographic microscopy and data clustering with discriminant analysis

Pierre Marquet, Daniel Boss

We propose to apply statistical clustering algorithms on a three-dimensional profile of red blood cells (RBCs) obtained through digital holographic microscopy (DHM). We show that two classes of RBCs stored for 14 and 38 days can be effectively classified. ...

2011

Improving Protein Pharmacokinetics by Engineering Erythrocyte Affinity

Jeffrey Alan Hubbell, Stephane Kontos

Poor pharmacokinetic profiles are often the underlying reason for the failure of novel protein drugs to reach clinical translation. Current passive half-life improvement methods focus on increasing the apparent hydrodynamic radius of the drug. We sought to ...

American Chemical Society2010

Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Daniel Boss, Annick Hoffmann

Red blood cell (RBC) membrane fluctuations provide important insights into cell states. We present a spatial analysis of red blood cell membrane fluctuations by using digital holographic Microscopy (DHM). This interferometric and dye-free technique, posses ...

Elsevier2009

Digital holographic microscopy applied to life sciences

Christian Depeursinge, Tristan Colomb, Benjamin Rappaz, Pierre Marquet, Florian Charrière, Jonas Kühn

Digital holographic microscopy (DHM) is applied to life sciences applications and demonstrate its capability of real-time imaging and quantitative measurements of physiological parameters such as cell volume or mean cell hemoglobin concentration (MCHC) of ...

IEEE2007

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