Concept

Addition nucléophile conjuguée

Publications associées (44)

Arginine-Specific Modification of Proteins with Polyethylene Glycol

In this study, the residue-selective modification of proteins with polymers at arginine residues is reported. The difficulty in modifying arginine residues lies in the fact that they are less reactive than lysine residues. Consequently, typical chemo-selec ...

2011

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

Pierre Vogel, Inmaculada Robina, Claudia Bello, Yolanda Vera-Ayoso

The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to hemiacetalic sugars followed by selective nucleophilic disp ...

2009

Effect of Mixing and Other Operating Parameters in Sol-Gel Processes

Paul Bowen

In this work the effect of mixing on a sol-gel process is quantitatively investigated. Titanium dioxide synthesis from titanium tetra-isopropoxide is used as a test reaction. Solutions of titanium alkoxide in isopropyl alcohol and water in isopropyl alcoho ...

2008

Ligand synthesis for homogeneous catalysis

Michael Maurin

Organophosphorus compounds found applications in varied fields of the organic chemistry: they are particularly present in natural compounds such as the deoxyribonucleic acid (DNA) and in the field of catalysis in which their utility is also proven. Thus, t ...

EPFL2007

Chasing an Elusive Alkoxide: Attempts to Synthesize [OC(tBu)(CF3)2]−

Rosario Scopelliti, Lutz Müller

The synthesis of the alkoxide [OC(tBu)(CF3)2]− by the reaction of tBuM-reagents (M = Li; MgX) with hexafluoroacetone was attempted. This alkoxide was anticipated to be a good building block for novel weakly coordinating anions. However, in all attempted sy ...

2006

New concise total synthesis of (+)-lentiginosine and some structural analogues

Pierre Vogel

An efficient and concise total synthesis of (+)-lentiginosine (1) starting from an L-tartaric acid-derived nitrone using organometallic addition, indium-catalyzed reduction, and ring-closing metathesis reaction as the key steps is reported. Structural anal ...

2005

Synthesis of aza-C-disaccharides (dideoxyimino-alditols C-linked to monosaccharides) and analogues

Pierre Vogel, Inmaculada Robina

The first aza-C-disaccharide (D-azaMan-beta-CHz-(1 -> 6)-D-Man-alpha-OMe) that mimicks alpha-D-Manp-(1 -> 6)-alpha-D-ManOMe was made in 1994 by Johnson and coworkers. Several synthetic approaches to these disaccharide mimetics have been proposed. These are ...

2005

Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds

The invention features polymeric biomaterials formed by nucleophilic addn. reactions to conjugated unsatd. groups. These biomaterials may be used for medical treatments. [on SciFinder (R)] ...

(Eidgenossische Technische Hochschule Zurich, Switz.; Universitat Zurich).2001

Diffusion-limited reactive wetting: Spreading of Cu-Sn-Ti alloys on vitreous carbon

Andreas Mortensen

When wetting is promoted by interfaces, the rate at which the liquid spreads over the solid substrate is controlled by the rate at which the well-wetted interfacial product can be formed along the liquid/solid/atmospheric triple line. If this reaction invo ...

2001

Synthesis and 13C NMR study of the triangulo-clusters [Pt3(m-CO)3-n(m-SO2)n(PR3)3] (n = 0-3)

Gabor Laurenczy, Raymond Roulet

[Pt-3(mu-CO)(3)(PPh3)(3)] was prepared in high yield by the reaction of [Pt-3(mu-CO)(3)(PPh3)(4)] with H2O2. The carbonyl ligands in [Pt-3(mu-CO)(3)(PR3)(3)] (PR3 = PPh3, PPh(2)Bz, PCy3, P'Pr-3) may be completely replaced by sulfur dioxide to give [Pt-3(mu ...

2000

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