Concept

Addition nucléophile conjuguée

Publications associées (44)

Benziodoxol(on)e Reagents as Tools in Organic Synthesis: The Background behind the Discovery at the Laboratory of Catalysis and Organic Synthesis

In this review, a personal account of our work in the field of hypervalent iodine reagents is presented. Pioneering experiments, which led to the discovery of the exceptional reactivity of EthynynnnlBenziodoXol( on)e (EBX) reagents as electrophilic alkyne ...

2016

Medium-Ring Effects on the Endo/Exo Selectivity of the Organocatalytic Intramolecular Diels-Alder Reaction

Esra Bozkurt

The intramolecular Diels-Alder reaction has been used as a powerful method to access the tricyclic core of the eunicellin natural products from a number of 9-membered-ring precursors. The endo/exo selectivity of this reaction can be controlled through a re ...

Amer Chemical Soc2015

Ligand-Controlled Regiodivergent Pathways of Rhodium(III)-Catalyzed Dihydroisoquinolone Synthesis: Experimental and Computational Studies of Different Cyclopentadienyl Ligands

Nicolai Cramer, Matthew Wodrich, Jérôme Florian Gonthier, Baihua Ye

Rh-III-catalyzed directed C-H functionalizations of arylhydroxamates have become a valuable synthetic tool. To date, the regioselectivity of the insertion of the unsaturated acceptor into the common cyclometalated intermediate was dependent solely on intri ...

Wiley-V C H Verlag Gmbh2014

Comprehensive kinetic model for the dissolution, reaction and crystallization processes involved in the synthesis of aspirin

Julien Léo Billeter

Kinetic modeling of batch reactions monitored by in-situ spectroscopy has been shown to be a helpful method for developing a complete understanding of reaction systems. Much work has been done to demonstrate the ability to model dissolution, reaction and c ...

Wiley-Blackwell2014

Isocyanoacetates as Synthetic Platform Towards Natural Products and Biologically Relevant Scaffolds

Thomas Bertrand Pascal Marie Buyck

My PhD work started with the development of a racemic access to trigonoliimine B, an hexacyclic alkaloid isolated in 2010. After having explored different strategies, we reported a 7-step synthesis of this natural product. This synthesis features a challen ...

EPFL2014

Chemical Oxidation of Dissolved Organic Matter by Chlorine Dioxide, Chlorine, And Ozone: Effects on Its Optical and Antioxidant Properties

Urs von Gunten, Silvio Canonica

In water treatment dissolved organic matter (DOM) is typically the major sink for chemical oxidants. The resulting changes in DOM, such as its optical properties have been measured to follow the oxidation processes. However, such measurements contain only ...

Amer Chemical Soc2013

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Abid Oueslati

Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body formation, and neurotoxicity in vivo. However, whether phosphorylation at thes ...

2012

SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels

Jeffrey Alan Hubbell

Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic r ...

2011

Ruthenium-Catalyzed Synthesis of 1,5-Dichlorides by Sequential Intermolecular Kharasch Reactions

Rosario Scopelliti, Kay Severin, Aurélien Godinat, Katrin Anne Thommes, Charlotte Buron

Sequential intermolecular atom transfer radical addition reactions of activated dichlorides Cl2CRR′ (R = CN, CO2Et, R′ = H, CN, CO2Et) with two olefins catalyzed by [Cp*RuCl2(PPh3)] in the presence Mg allow the synthesis of linear 1,5-dichlorides. Differen ...

Wiley-Blackwell2011

Ga2O3 photocatalyzed on-line tagging of cysteine to facilitate peptide mass fingerprinting

Hubert Girault, Liang Qiao, Hongyan Bi

beta-Ga2O3 is a wide-band-gap semiconductor having strong oxidation ability under light irradiation. Herein, the steel target plates modified with beta-Ga2O3 nanoparticles have been developed to carry out in-source photo-catalytic oxidative reactions for o ...

2011

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