Concept
Hypermutation somatique
Publications associées (12)
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Jessica Sordet, Natalya Katanayeva, Julien Racle, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly, Giovanni Ciriello, Marco Mina
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...
2020Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis
Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...
EPFL2020Phage selection of chemically stabilized alpha-helical peptide ligands
Christian Heinis, Pierre Vincent Dessen, Philippe Diderich, Davide Bertoldo, Maola Khan Mohammad Golam
Short alpha-helical peptides stabilized by linkages between constituent amino acids offer an attractive format for ligand development. In recent years, a range of excellent ligands based on stabilized alpha-helices were generated by rational design using a ...
2016Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Alizée Jéléna Grimm, Ziad Julier
Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...
Elsevier Sci Ltd2016Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia
Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...
Elsevier2016Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS
Yury Tsybin, Luca Fornelli, Daniel Ayoub
The rapid growth of approved biotherapeutics, e.g., monoclonal antibodies or immunoglobulins G (IgGs), demands improved techniques for their quality control. Traditionally, proteolysis-based bottom-up mass spectrometry (MS) has been employed. However, the ...
Amer Chemical Soc2014Advances in helminth immunology: optimism for future vaccine design?
Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate with disease morbidity and children generally harbor the largest numbers. The majority of intestinal helminths do not replicate within their host, and worm burdens ...
2011Polynucleotide cytidine deaminases, innate immunity and hepatitis B infection
More than 350 millions individuals worldwide suffer from chronic hepatitis B virus (HBV) infection, a condition that evolves towards liver insufficiency and hepatocellular carcinoma in approximately 15 to 40 percent of cases. Yet the majority of de novo HB ...
EPFL2007Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...
American Society for Biochemistry and Molecular Biology2007Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells
Kai Johnsson, Christian Heinis
A review. New, improved phenotypes. Somatic hypermutation in immune cells can be used for the fast directed evolution of proteins other than Igs (e.g., autofluorescent proteins). The target gene is inserted into the genome of activated B lymphocytes where ...
2005