Concept
Tumeur du sac vitellin
Publications associées (14)
KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma
Filipe Amândio Brandão Sanches Vong Martins
Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...
EPFL2023In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture
In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...
EPFL2022Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections
Martinus Gijs, Daniel Migliozzi, Diego Gabriel Dupouy, Benjamin Pelz
Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information about the immune ...
2019The role of Snail in non-small cell lung cancer
The epithelial-to-mesenchymal transition (EMT) is a developmental program frequently reactivated in cancer. It plays an important role in several aspects of tumor progression, particularly in the acquisition of invasive capacities facilitating metastasis. ...
EPFL2018In vivo cerebral metabolism of glioblastoma xenografts assessed with ¹H MRS, ¹³C MRS and ¹⁸F-FDG PET
Magnetic resonance spectroscopy (MRS) is a powerful tool when studying metabolism in intact and living organs preserving cells in their natural microenvironment with minimal external interference. The unique insights offered by the observation of metabolic ...
EPFL2017Exploring the potency of normal and pathological human thymic epithelial cells
Tiphaine Mélodie Chantal Arlabosse
Thymic epithelial cells (TECs) are organised in a unique 3D network that is critical for the development of efficient and self-tolerant T-cells. We report for the first time that the human thymus of all ages, even old and involuted, contains a significant ...
EPFL2017Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases
Michel Aguet, Stefania Rigotti, Maximilien Murone, Andres McAllister, Olivier Michielin
Tumor survival, metastases, chemoresistance, and escape from immune responses have been associated with inappropriate activation of STAT3 and/or STAT5 in various cancers, including solid tumors. Debio 0617B has been developed as a first-in-class kinase inh ...
Amer Assoc Cancer Research2016Proliferation, Morphology, and Pluripotency of Mouse Induced Pluripotent Stem Cells in Three Different Types of Alginate Beads for Mass Production
Induced pluripotent stem cells (iPSCs) are expected to be an ideal cell source for biomedical applications, but such applications usually require a large number of cells. Suspension culture of iPSC aggregates can offer high cell yields but sometimes result ...
Wiley-Blackwell2014Nodal.Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation
Daniel Constam, Christophe Fuerer
The TGF beta family member Nodal is central to control pluripotent stem cell fate, but its use as a stem cell differentiation factor is limited by low specific activity. During development, Nodal depends on growth and differentiation factor (Gdf)-1 and on ...
American Society for Biochemistry and Molecular Biology2014Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Manuel Andreas Fankhauser
Besides being a physical scaffold to maintain tissue morphology, the extracellular matrix (ECM) is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via biochemical, biomechanical, and b ...
Journal Of Visualized Experiments2014