Publications associées à Insulin signal transduction pathway

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Sandrine Gerber, Jutta Christine Wandrey, Redouan Mahou

Background: Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets. Methods: Human MSC ...

Biomed Central Ltd2017

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Johan Auwerx, Dongryeol Ryu

BACKGROUND & AIMS: Obesity-induced nonalcoholic fatty liver disease (NAFLD) develops, in part, via excess insulin-stimulated hepatic de novo lipogenesis, which increases, paradoxically, in patients with obesity-induced insulin resistance. Pleckstrin homolo ...

W B Saunders Co-Elsevier Inc2017

Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow

Theo Lasser, Paul James Marchand, Anne Grapin-Botton, Arno Pino Bouwens, Daniel Pawel Szlag, Corinne Berclaz, Jérôme Extermann, David Nguyen, Julia Sophie Katarina Nilsson

In diabetes, pancreatic beta-cells play a key role. These cells are clustered within structures called islets of Langerhans inside the pancreas and produce insulin, which is directly secreted into the blood stream. The dense vascularization of islets of La ...

Optical Soc Amer2016

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Carlos Canto Alvarez, Patrick Descombes, Sylviane Métairon

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD(+) -dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to ...

Elsevier2016

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

Carlos Canto Alvarez

Aging is the major risk factor for a constellation of multifactorial diseases, including insulin resistance, diabetes and cardiovascular complications. Dietary restriction has been shown to delay or prevent the manifestation of age-related health decline, ...

Cambridge Univ Press2016

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...

Elsevier Science Bv2015

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Henry Markram, Julie Meystre, Maurizio Ferdinando Pezzoli, Johannes Le Coutre, Susana Camacho Romero

Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin r ...

Nature Publishing Group2015

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

João Miguel das Neves Duarte

From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although ...

Int Soc Aging & Disease2015

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...

American Diabetes Association2015

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Insulin signal transduction pathway

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Glycosphingolipid–Protein Interaction in Signal Transduction

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

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Chattez avec Graph Search

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

Glycosphingolipid–Protein Interaction in Signal Transduction

Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Metabolic Alterations Associated to Brain Dysfunction in Diabetes