Concept

Modélisation de protéines par enfilage

Publications associées (55)

Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157

The bacterial Type 6 secretion system (T6SS) translocates protein toxins (also called effectors) from the cytosol of a T6SS-carrying cell to a target cell by a syringe-like supramolecular complex resembling a contractile tail of bacteriophages. Valine-glyc ...

Oxford University Press2014

Analysis of the accessibility of CLIP bound sites reveals that nucleation of the miRNA:mRNA pairing occurs preferentially at the 3'-end of the seed match

Jiri Vanicek, Ray Marcel Marin Florez, Thibaud Edouard Alistair von Erlach, Franziska Voellmy

To find out whether the AGO-miRNA complex is more sensitive to the accessibility of a particular region inside the seed match, we analyze in detail the accessibility of a wide set of miRNA binding sites validated by PAR-CLIP and HITS-CLIP experiments. Our ...

Cold Spring Harbor Lab Press, Publications Dept2012

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

Oliver Hantschel

Interactions between Src homology 2 (SH2) domains and phosphotyrosine sites regulate tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging due to the high homology among the 120 human SH2 domains. Using an improved ...

2010

Vibrational entropy and the structural organization of proteins

Paolo De Los Rios, Francesco Piazza

In this paper we analyze the vibrational spectra of a large ensemble of non-homologous protein structures by means of a novel tool, that we coin Hierarchical Network Model (HNM). Our coarse-grained scheme accounts for the intrinsic heterogeneity of force c ...

2010

Cnnm proteins and uses thereof

The present invention relates proteins from the group consisting of CNNM1, CNNM2, CNNM 3 and CNNM4, its derivatives or fragments thereof for use as a medicament, for treatment and or diagnostic purposes. The invention further relates to a human genomic DNA ...

2010

High robustness of correlation-based alignment with Penrose patterns to marker damage in electron beam lithography

Correlation-based alignment is an alternative alignment method for electron beam lithography. Using complex marker patterns, such as Penrose patterns, which contain more positional information, greater alignment accuracy can be achieved. Correlation-based ...

Elsevier2009

Conserved elements within open reading frames of mammalian Hox genes

Denis Duboule

A recent study in BMC Evolutionary Biology shows that many of the open reading frames in mammalian Hox genes are more conserved than expected on the basis of their protein sequence. The presence of highly conserved DNA elements is thus not confined to the ...

2009

A nanoporous reactor for efficient proteolysis

Liang Qiao, Yun Liu

A nanoreactor based on mesoporous silicates is described for efficient tryptic digestion of proteins within the mesochannels. Cyano-functionalized mesoporous silicate (CNS), with an average pore diameter of 18 nm, is a good support for trypsin, with rapid ...

2007

The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria

Stewart Cole

The gene Rv0813c from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is conserved within the order Actinomycetales but absent elsewhere. The crystal structure of Rv0813c reveals a new family of proteins that resembl ...

2006

A rivet model for channel formation by aerolysin-like pore-forming toxins

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

The bacterial toxin aerolysin kills cells by forming heptameric channels, of unknown structure, in the plasma membrane. Using disulfide trapping and cysteine scanning mutagenesis coupled to thiol-specific labeling on lipid bilayers, we identify a loop that ...

2006

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