Publications associées à Escherichia coli productrice de shigatoxines

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Sergey Nazarov, Petr Leiman, Sergii Buth, Nikolai Prokhorov, Michel Plattner

Bacteriophages recognize their host cells with the help of tail fiber and tailspike proteins that bind, cleave, or modify certain structures on the cell surface. The spectrum of ligands to which the tail fibers and tailspikes can bind is the primary determ ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2019

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Oliver Hantschel, Nadine Eliane Schmit, Katyayanee Neopane

Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to t ...

2019

Mechanism of Shiga Toxin Clustering on Membranes

Julian Charles Shillcock

The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, despite th ...

American Chemical Society2017

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Tristan Bolmont, Taoufiq Harach

The pathway leading from amyloid-b deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still unknown. AD brains featu ...

Elsevier Science Inc2017

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

Julian Charles Shillcock

The bacterial Shiga toxin is composed of an enzymatically active A-subunit, and a receptor-binding homopentameric B-subunit (STxB) that mediates intracellular toxin trafficking. Upon STxB-mediated binding to the glycolipid globotriaosylceramide (Gb3) at th ...

Royal Society of Chemistry2016

Pore-forming toxins: ancient, but never really out of fashion

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are fou ...

Nature Publishing Group2016

The Ins and Outs of Anthrax Toxin

Françoise Gisou van der Goot Grunberg

Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-gamma-D-glutamic a ...

Mdpi Ag2016

The effects of globotriaosylceramide tail saturation level on bilayer phases

Julian Charles Shillcock

Globotriaosylceramide (Gb(3)) is a glycosphingolipid present in the plasma membrane that is the natural receptor of the bacterial Shiga toxin. The unsaturation level of Gb(3) acyl chains has a drastic impact on lipid bilayer properties and phase behaviour, ...

Royal Soc Chemistry2015

Glucose- but Not Rice-Based Oral Rehydration Therapy Enhances the Production of Virulence Determinants in the Human Pathogen Vibrio cholerae

Andrea Rinaldo, Melanie Blokesch, Enrico Bertuzzo, Flavio Finger, Juliane Kühn, Marino Gatto

Despite major attempts to prevent cholera transmission, millions of people worldwide still must address this devastating disease. Cholera research has so far mainly focused on the causative agent, the bacterium Vibrio cholerae, or on disease treatment, but ...

2014

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Escherichia coli productrice de shigatoxines

Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Mechanism of Shiga Toxin Clustering on Membranes

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

Pore-forming toxins: ancient, but never really out of fashion

The Ins and Outs of Anthrax Toxin

The effects of globotriaosylceramide tail saturation level on bilayer phases

Glucose- but Not Rice-Based Oral Rehydration Therapy Enhances the Production of Virulence Determinants in the Human Pathogen Vibrio cholerae

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Chattez avec Graph Search

Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Pore-forming toxins: ancient, but never really out of fashion

The effects of globotriaosylceramide tail saturation level on bilayer phases

Mechanism of Shiga Toxin Clustering on Membranes

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

The Ins and Outs of Anthrax Toxin

Glucose- but Not Rice-Based Oral Rehydration Therapy Enhances the Production of Virulence Determinants in the Human Pathogen Vibrio cholerae