Concept

Vitamine

Publications associées (34)

Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus

Christof Holliger, Aamani Rupakula Boyanapalli

Corrinoids (derivatives of vitamin B12) are an essential cofactor of reductive dehalogenases, the key enzymes involved in the environmental-friendly process of organohalide respiration (OHR). However, genomic and physiological analyses of obligate OHR bact ...

2013

A vitamin B-12 transporter in Mycobacterium tuberculosis

John McKinney

Vitamin B-12-depende enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B-12 in vitro, it is uncertain whether the org ...

Royal Society, The2013

The corrinoid metabolism in desulfitobacterium hafniense - genetic and regulatory aspects

Christof Holliger, Julien Maillard, Emmanuelle Rohrbach, Aurélie Duret

Corrinoids (e.g. vitamin B12, cobalamin) represent a family of complex organometallic cofactors essential to the metabolism of microorganisms, animal and humans, and are involved in several enzymes such as isomerases, methyltransferases and reductive dehal ...

2012

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Philippe Renaud, Lynda Metref

Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments gener ...

2012

B12-BIOSYNTHESIS IN THE TETRACHLOROETHENE-RESPIRING OBLIGATE ANAEROBE DESULFITOBACTERIUM

Christof Holliger, Julien Maillard, Aurélie Duret

Tetrachloroethene (PCE) reductive dehalogenases are the key catalysts in the respiratory chain of dehalorespiring microorganisms, where they act as the terminal electron-accepting enzymes in the process. On protein level, reductive dehalogenases have been ...

2009

Physical properties and interactions of biomolecules

Mélanie Favre

The aim of this thesis was to explore the statistical physics and the mechanical properties of individual biomolecules, to study their interactions, and to develop new techniques based on atomic force microscopy (AFM). First, we exploit the high resolution ...

EPFL2008

Quantitative characterization of a recombinant Pichia pastoris Mut+ strain secreting avidin using transient continuous cultures

Carmen Jungo

The objective of this thesis was to characterize the growth stoichiometry, the specific recombinant protein productivity and the regulation of the alcohol oxidase (AOX) enzyme of a Pichia pastoris Mut+ strain, performing conventional chemostat cultures and ...

EPFL2007

Process for the preparation of 2-butene-1.4-diol

Albert Renken, Lioubov Kiwi, Eric Joannet

NOVELTY - A 2-butene-1,4-diol is prepared by hydrogenating 2-butyne-1,4-diol in the presence of a structured catalyst and in the absence of a solvent. USE - For preparing 2-butene-2,4-diol that is an important industrial intermediate in the preparation of ...

2005

Conformation-directed macrocyclization reactions

Jieping Zhu

A review. The importance of conformational pre-organization in successful macrocyclization reactions was recognized ever since Eschenmoser's synthesis of vitamin B12 and Woodward's synthesis of erythromycin. Different approaches to productive preorganizati ...

2005

Amperometric monitoring of redox activity in living yeast cells:comparison of menadione sodium bisulfite as electron transfer mediators

An amperometric method was applied for real-time monitoring of intracellular redox enzyme activity. Baker's yeast (Saccharomyces cerevisiae) cells were immobilized on platinum microband electrodes and mediated anodic currents were measured. The currents we ...

2004

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