Concept

Neurotoxine

Publications associées (58)

Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle

Pierre Magistretti, Jean-Luc Martin, Luc Pellerin

Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission, particularly during periods of intense activity. Since lactate does ...

1998

The compound channel capacity of a class of finite-state channels

Emre Telatar

A transmitter and receiver need to be designed to guarantee reliable communication on any channel belonging to a given family of finite-state channels defined over common finite input, output, and state alphabets. Both the transmitter and receiver are assu ...

1998

A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

In this paper, we have investigated the effects of the pore-forming toxin aerolysin, produced by Aeromonas hydrophila, on mammalian cells. Our data indicate that the protoxin binds to an 80-kD glycosyl-phosphatidylinositol (GPI)-anchored protein on BHK cel ...

1998

Glutamate uptake stimulates Na+,K+-ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain

Pierre Magistretti, Luc Pellerin

The excitatory amino acid glutamate was previously shown to stimulate aerobic glycolysis in astrocytes by a mechanism involving its uptake through an Na+-dependent transporter. Evidence had been provided that Na+,K+-ATPase might be involved in this process ...

1998

Aerolysin--the ins and outs of a model channel-forming toxin

Françoise Gisou van der Goot Grunberg

Aerolysin is one of a large group of bacterial proteins that can kill target cells by forming discrete channels in their plasma membranes. The toxin has many properties in common with the porins of the Gram-negative bacterial outer membrane, including an e ...

1996

Release of vasoactive intestinal peptide in mouse cerebral cortex: evidence for a role of arachidonic acid metabolites

Pierre Magistretti, Jean-Luc Martin

In rodent cerebral cortex, vasoactive intestinal peptide (VIP) is contained in a homogeneous population of radially oriented bipolar interneurons. We have observed that 4-aminopyridine (4-AP), a K+-channel blocker, promotes a concentration- and Ca2+-depend ...

1989

Presynaptic cholinergic action in the hippocampus

Henry Markram

The hippocampus is among the regions in the brain richest in M1 cholinergic receptors. Topical application of acetylcholine (ACh) onto hippocampal slices produces a characteristic complex response consisting of a depolarization, an increase in input resist ...

1989

An investigation of ethanol inhibition and other limitations occurring during the fermentation of concentrated whey permeate by Kluyveromyces fragilis

Urs von Stockar

Based on the well-known fact that K. fragilis strains show suboptimal performance when grown in concd. whey permeate, previously optimized medium was investigated for possible limitations appearing at high concns. Shaken flask cultures showed that no addnl ...

1985

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