Concept

Neurotoxine

Publications associées (58)

The biouptake and toxicity of arsenic species on the green microalga Chlorella salina in seawater

The present study focuses on the biouptake, biotransformations, and toxicity of arsenic species on the marine green alga Chlorella salina in seawater from the Bulgarian Black Sea coast. Exposure to equal concentrations of As(III) or As(V) led to equivalent ...

2008

Selective oxidation of key functional groups in cyanotoxins during drinking water ozonation

Urs von Gunten

Chemical kinetics were determined for the reactions of ozone and hydroxyl radicals with the three cyanotoxins microcystin-LR (MC-LR), cylindrospermopsin (CYN) and anatoxin-a (ANTX). The second-order rate constants (k(O3)) at pH 8 were 4.1 +/- 0.1 x 10(5) M ...

2007

Community and cultivation analysis of arsenite oxidizing biofilms at Hot Creek

Janet Gordon Hering

At Hot Creek in California, geothermally derived arsenite is rapidly oxidized to arsenate. This process is mediated by microorganisms colonizing the surfaces of submerged aquatic macrophytes in the creek. Here we describe a multifaceted approach to charact ...

2006

Reversible sequential-binding probe receptor-ligand interactions in single cells

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

With the reversible sequential (ReSeq) binding assay, we present a novel approach for the ultrasensitive profiling of receptor function in single living cells. This assay is based on the repetitive application of fluorescent ligands that have fast assocn.- ...

2005

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun, Diana Zala

Ciliary neurotrophic factor (CNTF) has been shown to prevent behavioral deficits and striatal degeneration in neurotoxic models of Huntington's disease (HD), but its effect in a genetic model has not been evaluated. Lentiviral vectors expressing the human ...

2004

Ganglion cells from chick retina display multiple functional nAChR subtypes

Mihai Adrian Ionescu, Philippe Renaud

We have examined the properties of nicotinic acetylcholine receptors in embryonic chick retinal ganglion cells. Ganglion cells, identified according to morphological and physiological criteria, displayed spontaneous or induced action potentials. In 94/99 c ...

2004

Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex

Pierre Magistretti, Pascal Steiner, Luc Pellerin, Jean-Yves Chatton, Egbert Welker

Neuron-glia interactions are essential for synaptic function, and glial glutamate (re)uptake plays a key role at glutamatergic synapses. In knockout mice, for either glial glutamate transporters, GLAST or GLT-1, a classical metabolic response to synaptic a ...

2003

Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes

Pierre Magistretti, Jean-Yves Chatton

The effects of inhibitors of the glial Na+/glutamate co-transporter on the intracellular Na+ concentration (Na+) were investigated in mouse cortical astrocytes. Na+ was monitored by fluorescence microscopy on single astrocytes using the Na+-sensi ...

2001

Effect of lateral connections on the accuracy of the population code for a network of spiking neurons

Wulfram Gerstner

We study how neuronal connections in a population of spiking neurons affect the accuracy of stimulus estimation. Neurons in our model code for a one-dimensional orientation variable

\phi

. Connectivity between two neurons depends on the absolute differenc ...

2001

Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones

Carl Petersen

The consequence of reduced uptake of neurotransmitters into synaptic vesicles on synaptic transmission was examined in rat hippocampal slices and culture using bafilomycin A1 (Baf), a potent and specific blocker of the vacuolar-type (V-type) ATPase, which ...

2000

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Effect of lateral connections on the accuracy of the population code for a network of spiking neurons

Wulfram Gerstner

We study how neuronal connections in a population of spiking neurons affect the accuracy of stimulus estimation. Neurons in our model code for a one-dimensional orientation variable

\phi

. Connectivity between two neurons depends on the absolute differenc ...

2001