Concept
Chemotherapy-induced peripheral neuropathy
Publications associées (38)
A Polyester–Nylon Blend Plantar Pressure Sensing Insole for Person With Diabetes
Yves Perriard, Yoan René Cyrille Civet, Paolo Germano, Sofia Lydia Ntella, Kenny Jeanmonod, Bhawnath Tiwari
Peripheral sensorimotor neuropathy among people with diabetes is one of the leading causes of foot ulceration. Plantar pressure is a significant parameter to control for the prevention of foot ulceration. A low-cost sensing insole, which can provide a reli ...
2023Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma
Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Irina Sinenko, Patrik Aouad
Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...
WILEY2023RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Cathrin Brisken, Ayyakkannu Ayyanan, Rachel Marcone
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (ROR). A cohort ...
NATURE PORTFOLIO2022Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial
Chronic pain is common after burn injuries, and post-burn neuropathic pain is the most important complication that is difficult to treat. Scrambler therapy (ST) is a non-invasive modality that uses patient-specific electrocutaneous nerve stimulation and is ...
MDPI2022Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defects contribute to SMA. Current SMA gene ther ...
2022The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy
Dominant mutations in ubiquitously expressed transfer RNA (tRNA) synthetase genes cause axonal peripheral neuropathy, accounting for at least six forms of Charcot-Marie-Tooth (CMT) disease. Genetic evidence in mouse and Drosophila models suggests a gain-of ...
AMER ASSOC ADVANCEMENT SCIENCE2021Plastic Changes in Pain and Motor Network Induced by Chronic Burn Pain
Musculoskeletal diseases with chronic pain are difficult to control because of their association with both central as well as the peripheral nervous system. In burn patients, chronic pain is one of the major complications that cause persistent discomfort. ...
MDPI2021Towards Light-Activated Ruthenium-Arene (RAPTA-Type) Prodrug Candidates
Paul Joseph Dyson, Rosario Scopelliti, Felix Daniel Bobbink, Patrycja Nowak-Sliwinska, Anna Katherine Renfrew
Cancer is currently one of the deadliest diseases worldwide. Based on the high incidence of this disease, the side effects associated with current chemotherapies and the appearance of drug resistance, considerable efforts have been directed towards the dev ...
WILEY-V C H VERLAG GMBH2019RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer
Mauro Delorenzi, Delphine Yvette L Grun
Colorectal cancer (CRC) is the third most frequent neoplastic disorder and is a main cause of tumor-related mortality, as many patients progress to stage IV metastatic CRC. Standard care consists of combination chemotherapy (FOLFIRI or FOLFOX). Patients wi ...
AMER SOC CLINICAL INVESTIGATION INC2019Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors
Douglas Hanahan, Gabriele Galliverti
High-risk human papillomavirus (HPV) are responsible for genital and oral cancers associated with the expression of the E6/E7 HPV oncogenes. Therapeutic vaccines targeting those oncogenes can only partially control tumor progression, highlighting the neces ...
BMC2019