Concept
Hormone stéroïdienne
Concepts associés (25)
Binding site
In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand. Ligands may include other proteins (resulting in a protein-protein interaction), enzyme substrates, second messengers, hormones, or allosteric modulators. The binding event is often, but not always, accompanied by a conformational change that alters the protein's function.
3α-Androstanediol
3α-Androstanediol also known as 5α-androstane-3α,17β-diol and sometimes shortened in the literature to 3α-diol, is an endogenous steroid hormone and neurosteroid and a metabolite of androgens like dihydrotestosterone (DHT). 3α-Androstanediol is an inhibitory androstane neurosteroid and weak androgen and estrogen. As a neurosteroid, it acts as a potent positive allosteric modulator of the GABAA receptor, and has been found to have rewarding, anxiolytic, pro-sexual, and anticonvulsant effects.
Corticostérone
La corticostérone est une hormone corticostéroïde sécrétée par le cortex (plus précisément dans la zone fasciculée) de la glande surrénale à partir du cholestérol et sous la dépendance de l'ACTH hypophysaire. Elle interfère notamment avec la sensation de peur mémorisée et avec la mémoire. Comme les autres glucocorticoïdes, elle peut modifier l’activité cérébrale et le comportement via des mécanismes génomiques classiques (on parle d'« effet nucléaire » car basé dans le noyau de neurones sur la transcription de gènes et la synthèse protéique, ce qui implique - pour ces effets - une latence longue entre l’exposition à la corticostérone et l'apparition d'une réponse).
Serum albumin
Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood. Human serum albumin is encoded by the ALB gene. Other mammalian forms, such as bovine serum albumin, are chemically similar. Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals. Albumin is essential for maintaining the oncotic pressure needed for proper distribution of body fluids between blood vessels and body tissues; without albumin, the high pressure in the blood vessels would force more fluids out into the tissues.
Membrane progesterone receptor
Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Unlike the progesterone receptor (PR), a nuclear receptor which mediates its effects via genomic mechanisms, mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades.