Concept

Nucleus (neuroanatomy)

Publications associées (50)

Quantitative Susceptibility Mapping in the Human Brain

Magnetic resonance imaging (MRI) offers a good tissue contrast and the ability to visualize many disease related morphologies. The work presented in this thesis investigates the study of underlying structure of the brain using quantitative methods with a s ...

EPFL2016

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Sébastien Mosser

Alzheimer s disease (AD) is a devastating neurodegenerative disease characterized by strong cognitive impairment and memory loss. These symptoms are caused by neuronal death, induced by two pathological hallmarks: extracellular senile plaques composed of a ...

EPFL2016

Anatomically-adapted graph wavelets for improved group-level fMRI activation mapping

Dimitri Nestor Alice Van De Ville, Hamid Behjat, Nora Leonardi

A graph based framework for fMRI brain activation mapping is presented. The approach exploits the spectral graphwavelet transform (SGWT) for the purpose of defining an advanced multi-resolutional spatial transformation for fMRI data. The framework extends ...

Elsevier2015

A three-dimensional self-opening intraneural peripheral interface (SELINE)

Silvestro Micera

Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that prov ...

Iop Publishing Ltd2015

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Meritxell Bach Cuadra, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Alexis Roche, Guillaume Bonnier

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...

Elsevier2015

Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models

Nicolas Kunz, Kieran O'Brien, François Lazeyras, Hui Zhang

Brain white matter connections have become a focus of major interest with important maturational processes occurring in newborns. To study the complex microstructural developmental changes in-vivo, it is imperative that non-invasive neuroimaging approaches ...

Elsevier2014

New tool for studying the biosynthetic role of glucose in brain at the nanometer scale

Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi

Background: The brain consumes a considerable amount of glucose relative to its size. Brain glucose is a source of energy, mainly via oxidative phosphorylation, as well as a source of building blocks for synthesising macromolecules. Little is known about t ...

2014

New Developments and Applications of the MP2RAGE Sequence - Focusing the Contrast and High Spatial Resolution R1 Mapping

Rolf Gruetter, José Pedro Rebelo Ferreira Marques

MR structural T1-weighted imaging using high field systems (>3T) is severely hampered by the existing large transmit field inhomogeneities. New sequences have been developed to better cope with such nuisances. In this work we show the potential of a recent ...

Public Library of Science2013

Reduced Fronto-Temporal and Limbic Connectivity in the 22q11.2 Deletion Syndrome: Vulnerability Markers for Developing Schizophrenia?

Jean-Philippe Thiran, Leila Cammoun, Marie Schaer

The 22q11.2 deletion syndrome (22q11DS) is a widely recognized genetic model allowing the study of neuroanatomicalvbiomarkers that underlie the risk for developing schizophrenia. Recent advances in magnetic resonance image analysesvenable the examination o ...

Public Library of Science2013

Morphology-driven automatic segmentation of MR images of the neonatal brain

Michel Kocher, Laura Ioana Gui, François Lazeyras, Radoslaw Lisowski

The segmentation of MR images of the neonatal brain is an essential step in the study and evaluation of infant brain development. State-of-the-art methods for adult brain MRI segmentation are not applicable to the neonatal brain, due to large differences i ...

Elsevier Science Bv2012

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