Concept

Substituted tryptamine

Publications associées (32)

Preparation of asymmetrically substituted biaryldiphosphines as ligands for enantioselective hydrogenation

Provided is a process for prepn. of asym. substituted biaryldiphosphine ligands I (R1 = C1-6-alkyl, C3-10-cycloalkyl optionally substituted with one or more halogen atoms; R2, R3 = aryl, C5-10-cycloalkyl, C1-6-alkyl, or R2 = C5-10-cycloalkyl, C1-6-alkyl; R ...

(Lonza AG, Switz.).2006

Mutants of o6-alkylguanine-dna alkyltransferase

Kai Johnsson, Christian Heinis, Alexandre Juillerat, Christopher Chidley, Thomas Gronemeyer, Antje Keppler

The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted ...

2006

The regiochemically flexible functionalization of fluoro-and trifluoromethyl-substituted indoles

Assunta Ginanneschi

The use of organometallic reagents for functionalization of arenes and heterocycles has recently been renewed by our group. The use of bulky trialkylsilyl groups allows one to shield an acidic position by steric hindrance and the introduction of a chlorine ...

EPFL2005

Mutants of human O6-alkylguanine-DNA alkyltransferase with improved properties

Kai Johnsson, Christian Heinis, Alexandre Juillerat, Christopher Chidley, Thomas Gronemeyer, Antje Keppler

The invention relates to human O6-alkylguanine-DNA alkyltransferase (hAGT) mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localization of the expressed protein i ...

(EPFL Ecole Polytechnique Federale de Lausanne, Switz.).2005

Synthesis of N-substituted (3S,4S)- and (3R,4R)-pyrrolidine-3,4-diols: Search for new glycosidase inhibitors

Pierre Vogel

N-Substituted (3S,4S)- and (3R,4R)-pyrrolidine-3,4-diols 9 and 10, respectively, were derived from (+)-L- and (-)-D-tartaric acid, respectively. Compounds 9k, 91, and 9m with the N-substituents, BnNH(CH2)(2), 4-Phc(6)H(4)CH(2)NH(CH2)(2) and 4-ClC6H4CH2NH(C ...

2004

Trifluoromethoxy Substituted Anilines: Metalation as the Key Step for Structural Elaboration

Trifluoromethoxy-substituted anilines undergo hydrogen/lithium permutation ("metalation") with optional site selectivity depending on the N-protective group employed. N-tert-Butoxycarbonyl-2- and -4-(trifluoromethoxy)aniline react with tert-BuLi at the n ...

2003

Lanthanide chromite-based sofc anodes

Ravindranathan Thampi, Joseph Sfeir

A SOFC, with a solid electrolyte layer and at least one anode layer constituting a stratified structure. The anode layer incorporates a twice substituted lanthanide chromite, substituted by Sr on A sites and by Ni or Cu on B sites. The stratified structure ...

2003

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization

It was possible to functionalize the three fluorobenzyl alcs. and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an ...

2002

Three complementary methods offering access to 5-substituted 1,2,3,4-tetrahydroisoquinolines

The scope and limitations of three independent, though related routes leading to 5-substituted tetrahydroisoquinolines are explored: the Pictet-Spengler type cyclization of ortho-substituted 2-phenylethylamines, the Pomeranz-Fritsch type cyclization of met ...

1998

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

Michel Aguet

Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integratio ...

1995

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