Concept

Rétinite pigmentaire

Publications associées (116)

Early apoptosis of rod photoreceptors in Rpe65(-/-) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes

RPE65-related Leber's congenital amaurosis (LCA) is a rod-cone dystrophy whose clinical outcome is mainly attributed to the loss of rod photoreceptors followed by cone degeneration. Pathogenesis in Rpe65-/- mice is characterized by a slow and progressive d ...

2012

Organic electronics allows the photo-electric excitation and inhibition of neuronal activity in primary neuronal cultures and acute retinal explants

Diego Ghezzi

Interfacing organic electronics and biology offers new possibilities in biotechnology, due to the unique properties exhibited by organic conducting polymers (e.g. biological affinity, mechanical flexibility and ease of functionalization). OCP have been exp ...

2012

Double Concentric Autofluorescence Ring in NR2E3-p.G56R-Linked Autosomal Dominant Retinitis Pigmentosa

Pascal Escher

PURPOSE. We reported an unusual appearance of fundus autofluorescence (FAF) associated with NR2E3-p.G56R-linked autosomal dominant retinitis pigmentosa (ADRP). METHODS. Patients were enrolled among three generations in a Swiss family. Molecular diagnosis i ...

Assoc Research Vision Ophthalmology Inc2012

Nonvisual light-response model: a preliminary approach to integrating recent findings in biology into a lighting simulation process

Marilyne Andersen, María Lovísa Ámundadóttir, Steven W. Lockley

In addition to stimulating visual responses, light induces a range of circadian, neuroendocrine and neurobehavioral non-visual responses in humans. These effects are mediated primarily via a novel non-rod, non-cone photoreceptor, which is most sensitive to ...

2012

Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Filippo Piffaretti

The hydrodynamic rebalancing laser (HRL) procedure is an ophthalmic therapy based on the administration of subthreshold infrared (810 nm) laser light to selected areas on the retina to treat various retina diseases. Heterogeneities of tissue response are o ...

Spie-Soc Photo-Optical Instrumentation Engineers2012

Simulations to study spatial extent of stimulation and effect of electrode–tissue gap in subretinal implants

Philippe Renaud, Arnaud Bertsch, Sri Harsha Kasi Raj

We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode–tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to ...

Elsevier2011

Analysis of Factors Affecting the Performance of Retinal Prostheses Using Finite Element Modelling of Electric Field Distribution in the Retina

Sri Harsha Kasi Raj

This dissertation proposes a computational framework targeted at improving the design of currently employed retinal prostheses. The framework was used for analysing factors impacting the performance of prostheses in terms of electrical stimulation for reti ...

EPFL2011

Altered Expression of the Transcription Factor Mef2c during Retinal Degeneration in Rpe65(-/-) Mice

Pascal Escher

PURPOSE. To investigate the role of the myocyte enhancer factor 2 (Mef2) transcription factor family in retinal diseases, Mef2c expression was assessed during retinal degeneration in the Rpe65(-/-) mouse model of Leber's congenital amaurosis (LCA). Mef2c-d ...

2011

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa

Didier Trono, Anna Claire Groner

Retinitis pigmentosa refers to a diverse group of hereditary diseases affecting two million people worldwide that lead to incurable blindness. As a common pathology, rod photoreceptors die early whereas light-insensitive, morphologically altered cone photo ...

American Association for the Advancement of Science2010

Variable phenotypic expressivity in a Swiss family with autosomal dominant retinitis pigmentosa due to a T494M mutation in the PRPF3 gene

Purpose: To characterize the clinical, psychophysical, and electrophysiological phenotypes in a five-generation Swiss family with dominantly inherited retinitis pigmentosa caused by a T494M mutation in the Precursor mRNA-Processing factor 3 (PRPF3) gene, a ...

2010

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