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RPE65-related Leber's congenital amaurosis (LCA) is a rod-cone dystrophy whose clinical outcome is mainly attributed to the loss of rod photoreceptors followed by cone degeneration. Pathogenesis in Rpe65-/- mice is characterized by a slow and progressive d ...
Interfacing organic electronics and biology offers new possibilities in biotechnology, due to the unique properties exhibited by organic conducting polymers (e.g. biological affinity, mechanical flexibility and ease of functionalization). OCP have been exp ...
Retinitis pigmentosa refers to a diverse group of hereditary diseases affecting two million people worldwide that lead to incurable blindness. As a common pathology, rod photoreceptors die early whereas light-insensitive, morphologically altered cone photo ...
American Association for the Advancement of Science2010
PURPOSE. To investigate the role of the myocyte enhancer factor 2 (Mef2) transcription factor family in retinal diseases, Mef2c expression was assessed during retinal degeneration in the Rpe65(-/-) mouse model of Leber's congenital amaurosis (LCA). Mef2c-d ...
Purpose: To characterize the clinical, psychophysical, and electrophysiological phenotypes in a five-generation Swiss family with dominantly inherited retinitis pigmentosa caused by a T494M mutation in the Precursor mRNA-Processing factor 3 (PRPF3) gene, a ...
In addition to stimulating visual responses, light induces a range of circadian, neuroendocrine and neurobehavioral non-visual responses in humans. These effects are mediated primarily via a novel non-rod, non-cone photoreceptor, which is most sensitive to ...
The hydrodynamic rebalancing laser (HRL) procedure is an ophthalmic therapy based on the administration of subthreshold infrared (810 nm) laser light to selected areas on the retina to treat various retina diseases. Heterogeneities of tissue response are o ...
We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode–tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to ...
PURPOSE. We reported an unusual appearance of fundus autofluorescence (FAF) associated with NR2E3-p.G56R-linked autosomal dominant retinitis pigmentosa (ADRP). METHODS. Patients were enrolled among three generations in a Swiss family. Molecular diagnosis i ...
This dissertation proposes a computational framework targeted at improving the design of currently employed retinal prostheses. The framework was used for analysing factors impacting the performance of prostheses in terms of electrical stimulation for reti ...