Concept
Adenomatous polyposis coli
Publications associées (38)
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling
Bcl9 and Pygopus (Pygo) are obligate Wnt/beta-catenin cofactors in Drosophila, yet their contribution to Wnt signaling during vertebrate development remains unresolved. Combining zebrafish and mouse genetics, we document a conserved, beta-catenin-associate ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2018CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer
Michel Aguet, Patrick Rodriguez, Mauro Delorenzi, Pascale Anderle Pedone, Andreas Eduard Moor, Norbert Wiedemann, Sylvie André Baflast, Frédérique Baruthio
BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...
Elsevier Science Bv2015The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer
Aberrantly active Wnt signaling is the hallmark driver of colorectal cancer (CRC). Bcl9/9l proteins are components of the main transcriptional activation complex of canonical Wnt signaling and interact with beta-catenin via a highly conserved homology doma ...
EPFL2014The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription
Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent beta-catenin coactivators, with Pygo2 playing the more important role. All P ...
Company Of Biologists Ltd2013