Concept

Genetic variation

Publications associées (224)

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human association studies might prove powerful and was exploit ...

Public Library of Science2009

A typical relaxation of structural constraints in Hox gene clusters of squamates

Denis Duboule

Hox genes control many aspects of embryonic development in metazoans. Previous analyses of this gene family has revealed a surprising diversity in terms of gene number and organization between various animal species. In vertebrates, Hox genes are grouped i ...

Elsevier Science BV2009

Morphology, Biometry, and Taxonomy of Freshwater and Marine Interstitial Cyphoderia (Cercozoa: Euglyphida)

Edward Mitchell, Thierry Jean Heger

Good taxonomy is essential for ecological, biogeographical, and evolutionary studies of any group of organisms. Therefore, we performed detailed light- and scanning electron microscopy (SEM) investigations on the shell ultrastructure and biometric analyses ...

2009

Statistical Assessment of Variability of Terminal Restriction Fragment Length Polymorphism Analysis Applied to Complex Microbial Communities

Christof Holliger, Pierre Rossi, Emmanuelle Rohrbach, François Gillet, Nouhou Diaby

The variability of terminal restriction fragment polymorphism analysis applied to complex microbial communities was assessed statistically. Recent technological improvements were implemented in the successive steps of the procedure, resulting in a standard ...

American Society for Microbiology2009

Genetic background determines metabolic phenotypes in the mouse

Johan Auwerx

To evaluate the contribution of genetic background to phenotypic variation, we compared a large range of biochemical and metabolic parameters at different ages of four inbred mice strains, C57BL/6J, 129SvPas, C3HeB/FeJ, and Balb/cByJ. Our results demonstra ...

2008

The fixation of locally beneficial alleles in a metapopulation

Séverine Vuilleumier Varisco, Nicolas Perrin

Extinction, recolonization and local adaption are common in natural spatially structured populations. Understanding their effect upon genetic variation is important for systems such as GMO management, or avoidance of drug resistance. Theoretical studies on ...

2008

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

Denis Duboule

During the development of mammalian digits, clustered Hoxd genes are expressed following a collinear regulatory strategy, leading to both the growth of digits and their morphological identities. Because gene dosage is a key parameter in this system, we use ...

2008

Reduction of Register File Delay Due to Process Variability in VLIW Embedded Processors

Giovanni De Micheli, David Atienza Alonso, José Luis Ayala Rodrigo

Process variation in future technologies can cause severe performance degradation since different parts of the shared Register File (RF) in VLIW processors may operate at various speeds. In this paper we present a complete approach that handles speed varia ...

2007

Conserved oviposition preferences in alpine leaf beetle populations despite host shifts and isolation

Anthony Christopher Davison

Choosing the plant on which to lay their eggs is the last act of care that most female herbivorous insects bestow upon their offspring. These decisions play a pivotal role in insect–plant interactions, placing host preference under strong selection and ...

2007

Vers la maîtrise de la qualité des assemblages de précision

Fabien Bourgeois

In several industrial case studies, we put in evidence that microsystem manufacturing costs skyrocket because of low yields. Sometimes product functionalities are badly defined ; sometimes metrology systems, in spite of their high cost, happen not to measu ...

EPFL2007

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