Concept

Chimie combinatoire

Publications associées (68)

Metal-Based Chemosensors for Important Bioanalytes

This work describes different strategies for the detection of biologically relevant analytes. The main goal was to achieve sensing in water, which is a prerequisite for application to real biological samples. In several cases, we could demonstrate that our ...

EPFL2010

On Exploring Genome Rearrangement Phylogenetic Patterns

Wei Xu

The study of genorne rearrangement is much harder than the corresponding problems on DNA and protein sequences, because of the occurrences of numerous combinatorial structures. By explicitly exploring these combinatorial structures, the recently developed ...

Springer-Verlag New York2010

Sensing with Dynamic Combinatorial Libraries of Metal-Dye Complexes: The Advantage of Time-Resolved Measurements

Kay Severin, Friederike Gundula Marie Zaubitzer

A dynamic combinatorial library of metal–dye complexes was obtained by reacting aqueous solutions of the dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange with CuCl2 and NiCl2. The mixture gave a characteristic UV-Vis response upon addition of the p ...

2009

A post-modification approach to peptide foldamers

Harm-Anton Klok, Laure Menin, Nadja Franz

Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide folda ...

Royal Society of Chemistry2009

A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling

Stewart Cole, Edina Rita Székely, Gabor Nemeth

The Mycobacterium tuberculosis genome encodes for eleven eukaryotic-like Ser/Thr protein kinases. At least three of these (PknA, PknB and PknG) are essential for bacterial growth and survival. PknG is secreted by pathogenic mycobacteria, in macrophages to ...

2008

Utilization of Self-Sorting Processes to Generate Dynamic Combinatorial Libraries with New Network Topologies

Rosario Scopelliti, Kay Severin

The synthesis of water-sol., organometallic macrocycles is described. They were obtained by self-assembly in reactions of the half-sandwich complexes [{Ru(C6H5Me)Cl2}2], [{Ru(p-cymene)Cl2}2], [{Rh(Cp)Cl2}2], and [{Ir(Cp*)Cl2}2] with the ligand 5-dimethylam ...

2006

Selection experiments with dynamic combinatorial libraries: the importance of the target concentration

Kay Severin

Experimental data are presented which demonstrate that the target concentration has a strong influence on the outcome of selection experiments with a dynamic mixture of self-assembled receptors. ...

2005

MEMS tools for combinatorial materials processing and high-throughput characterization

Jürgen Brugger, Alfred Ludwig

Using the combinatorial material synthesis approach, materials libraries can be produced in one experiment that contain up to several thousand samples on a single substrate. In order to identify optimized materials in an efficient way using screening metho ...

2005

Conformation-directed macrocyclization reactions

Jieping Zhu

A review. The importance of conformational pre-organization in successful macrocyclization reactions was recognized ever since Eschenmoser's synthesis of vitamin B12 and Woodward's synthesis of erythromycin. Different approaches to productive preorganizati ...

2005

Dynamic Combinatorial Libraries of Dye-Complexes as Sensors

Kay Severin, Andrey Buryak

A simple soln.: Simply dissolving three com. available dyes and two metal salts in a buffer is sufficient to create a sensor which allows the identification of dipeptides with high selectivity by using UV/Vis spectroscopy (see picture for the adaptive beha ...

2005

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